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Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care

Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses...

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Detalles Bibliográficos
Autores principales: Zhang, Jinyuan, Kim, Kyunghun, Kim, Ho Joong, Meyer, Dawn, Park, Woohyun, Lee, Seul Ah, Dai, Yumin, Kim, Bongjoong, Moon, Haesoo, Shah, Jay V., Harris, Keely E., Collar, Brett, Liu, Kangying, Irazoqui, Pedro, Lee, Hyowon, Park, Shin Ae, Kollbaum, Pete S., Boudouris, Bryan W., Lee, Chi Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489713/
https://www.ncbi.nlm.nih.gov/pubmed/36127347
http://dx.doi.org/10.1038/s41467-022-33254-4
Descripción
Sumario:Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care.