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Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care
Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489713/ https://www.ncbi.nlm.nih.gov/pubmed/36127347 http://dx.doi.org/10.1038/s41467-022-33254-4 |
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author | Zhang, Jinyuan Kim, Kyunghun Kim, Ho Joong Meyer, Dawn Park, Woohyun Lee, Seul Ah Dai, Yumin Kim, Bongjoong Moon, Haesoo Shah, Jay V. Harris, Keely E. Collar, Brett Liu, Kangying Irazoqui, Pedro Lee, Hyowon Park, Shin Ae Kollbaum, Pete S. Boudouris, Bryan W. Lee, Chi Hwan |
author_facet | Zhang, Jinyuan Kim, Kyunghun Kim, Ho Joong Meyer, Dawn Park, Woohyun Lee, Seul Ah Dai, Yumin Kim, Bongjoong Moon, Haesoo Shah, Jay V. Harris, Keely E. Collar, Brett Liu, Kangying Irazoqui, Pedro Lee, Hyowon Park, Shin Ae Kollbaum, Pete S. Boudouris, Bryan W. Lee, Chi Hwan |
author_sort | Zhang, Jinyuan |
collection | PubMed |
description | Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care. |
format | Online Article Text |
id | pubmed-9489713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94897132022-09-22 Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care Zhang, Jinyuan Kim, Kyunghun Kim, Ho Joong Meyer, Dawn Park, Woohyun Lee, Seul Ah Dai, Yumin Kim, Bongjoong Moon, Haesoo Shah, Jay V. Harris, Keely E. Collar, Brett Liu, Kangying Irazoqui, Pedro Lee, Hyowon Park, Shin Ae Kollbaum, Pete S. Boudouris, Bryan W. Lee, Chi Hwan Nat Commun Article Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce a class of smart soft contact lenses, enabling the continuous 24-hour monitoring of intraocular pressure, even during sleep. Uniquely, the smart soft contact lenses are built upon various commercial brands of soft contact lenses without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that the smart soft contact lenses can seamlessly fit across different corneal curvatures and thicknesses in human eyes and therefore accurately measure absolute intraocular pressure under ambulatory conditions. We perform a comprehensive set of in vivo evaluations in rabbit, dog, and human eyes from normal to hypertension to confirm the superior measurement accuracy, within-subject repeatability, and user comfort of the smart soft contact lenses beyond current wearable ocular tonometers. We envision that the smart soft contact lenses will be effective in glaucoma care. Nature Publishing Group UK 2022-09-20 /pmc/articles/PMC9489713/ /pubmed/36127347 http://dx.doi.org/10.1038/s41467-022-33254-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Jinyuan Kim, Kyunghun Kim, Ho Joong Meyer, Dawn Park, Woohyun Lee, Seul Ah Dai, Yumin Kim, Bongjoong Moon, Haesoo Shah, Jay V. Harris, Keely E. Collar, Brett Liu, Kangying Irazoqui, Pedro Lee, Hyowon Park, Shin Ae Kollbaum, Pete S. Boudouris, Bryan W. Lee, Chi Hwan Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title | Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title_full | Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title_fullStr | Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title_full_unstemmed | Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title_short | Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
title_sort | smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489713/ https://www.ncbi.nlm.nih.gov/pubmed/36127347 http://dx.doi.org/10.1038/s41467-022-33254-4 |
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