Systematic profiling of conditional degron tag technologies for target validation studies

Conditional degron tags (CDTs) are a powerful tool for target validation that combines the kinetics and reversible action of pharmacological agents with the generalizability of genetic manipulation. However, successful design of a CDT fusion protein often requires a prolonged, ad hoc cycle of constr...

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Detalles Bibliográficos
Autores principales: Bondeson, Daniel P., Mullin-Bernstein, Zachary, Oliver, Sydney, Skipper, Thomas A., Atack, Thomas C., Bick, Nolan, Ching, Meilani, Guirguis, Andrew A., Kwon, Jason, Langan, Carly, Millson, Dylan, Paolella, Brenton R., Tran, Kevin, Wie, Sarah J., Vazquez, Francisca, Tothova, Zuzana, Golub, Todd R., Sellers, William R., Ianari, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489723/
https://www.ncbi.nlm.nih.gov/pubmed/36127368
http://dx.doi.org/10.1038/s41467-022-33246-4

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