Structure of the PAPP-A(BP5) complex reveals mechanism of substrate recognition

Insulin-like growth factor (IGF) signaling is highly conserved and tightly regulated by proteases including Pregnancy-Associated Plasma Protein A (PAPP-A). PAPP-A and its paralog PAPP-A2 are metalloproteases that mediate IGF bioavailability through cleavage of IGF binding proteins (IGFBPs). Here, we...

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Detalles Bibliográficos
Autores principales: Judge, Russell A., Sridar, Janani, Tunyasuvunakool, Kathryn, Jain, Rinku, Wang, John C. K., Ouch, Christna, Xu, Jun, Mafi, Amirhossein, Nile, Aaron H., Remarcik, Clint, Smith, Corey L., Ghosh, Crystal, Xu, Chen, Stoll, Vincent, Jumper, John, Singh, Amoolya H., Eaton, Dan, Hao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489782/
https://www.ncbi.nlm.nih.gov/pubmed/36127359
http://dx.doi.org/10.1038/s41467-022-33175-2

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