Cargando…

Screening microbially produced Δ(9)-tetrahydrocannabinol using a yeast biosensor workflow

Microbial production of cannabinoids promises to provide a consistent, cheaper, and more sustainable supply of these important therapeutic molecules. However, scaling production to compete with traditional plant-based sources is challenging. Our ability to make strain variants greatly exceeds our ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shaw, William M., Zhang, Yunfeng, Lu, Xinyu, Khalil, Ahmad S., Ladds, Graham, Luo, Xiaozhou, Ellis, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489785/ https://www.ncbi.nlm.nih.gov/pubmed/36127350 http://dx.doi.org/10.1038/s41467-022-33207-x

Ejemplares similares

Continuous-Flow Synthesis of Δ(9)-Tetrahydrocannabinol and Δ(8)-Tetrahydrocannabinol from Cannabidiol
por: Bassetti, Benedetta, et al.
Publicado: (2023)

Toxicological Properties of Δ(9)-tetrahydrocannabinol and Cannabidiol
por: Černe, Katarina
Publicado: (2020)

Development of a plant-produced recombinant monoclonal antibody against Δ-9-tetrahydrocannabinol (Δ9-THC) for immunoassay application
por: Boonyayothin, Wanuttha, et al.
Publicado: (2022)

Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
por: Castelli, M. Paola, et al.
Publicado: (2014)

Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide
por: Hassenberg, Christoph, et al.
Publicado: (2020)

Δ(9)-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure
por: Miller, Sally, et al.
Publicado: (2018)

The dimerization of Δ(9)-tetrahydrocannabinolic acid A (THCA-A)
por: Cuadari, Arben, et al.
Publicado: (2019)

Acute human exposure assessment to tetrahydrocannabinol (Δ(9)‐THC)
por: Arcella, Davide, et al.
Publicado: (2020)

Δ(9)-tetrahydrocannabinol discrimination: Effects of route of administration in mice
por: Marusich, Julie A., et al.
Publicado: (2023)

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial
por: Zamarripa, C. Austin, et al.
Publicado: (2023)

Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity
por: Samarut, Éric, et al.
Publicado: (2019)

Genetic Dissection of Behavioural and Autonomic Effects of Δ(9)-Tetrahydrocannabinol in Mice
por: Monory, Krisztina, et al.
Publicado: (2007)

Cannabis sativa (Hemp) Seeds, Δ(9)-Tetrahydrocannabinol, and Potential Overdose
por: Yang, Yi, et al.
Publicado: (2017)

Selective effects of Δ(9)-tetrahydrocannabinol on medium spiny neurons in the striatum
por: Fernández-Cabrera, Mónica R., et al.
Publicado: (2018)

Cannabidiol Does Not Convert to Δ(9)-Tetrahydrocannabinol in an In Vivo Animal Model
por: Wray, Louise, et al.
Publicado: (2017)

Tolerance and dependence to Δ(9)-tetrahydrocannabinol in rhesus monkeys: Activity assessments
por: Wilkerson, Jenny L., et al.
Publicado: (2019)

Δ(9)‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo
por: Huerga‐Gómez, Alba, et al.
Publicado: (2020)

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol
por: Rao, Qianru, et al.
Publicado: (2022)

Identification of Terpenoid Chemotypes Among High (−)-trans-Δ(9)- Tetrahydrocannabinol-Producing Cannabis sativa L. Cultivars
por: Fischedick, Justin T.
Publicado: (2017)

Δ(9)-Tetrahydrocannabinol Experience Influences ΔFosB and Downstream Gene Expression in Prefrontal Cortex
por: Lazenka, Matthew F., et al.
Publicado: (2017)

Identification of candidate genes affecting Δ(9)-tetrahydrocannabinol biosynthesis in Cannabis sativa
por: Marks, M. David, et al.
Publicado: (2009)

Sex and Strain Variation in Initial Sensitivity and Rapid Tolerance to Δ9–Tetrahydrocannabinol
por: Parks, Cory, et al.
Publicado: (2020)

Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
por: Escudero-Lara, Alejandra, et al.
Publicado: (2020)

Adverse effects of Δ(9)-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
por: Beiersdorf, Johannes, et al.
Publicado: (2020)

Cannabis Use and Neuroadaptation: A Call for Δ(9)-Tetrahydrocannabinol Challenge Studies
por: Ramaekers, Johannes G., et al.
Publicado: (2022)

Combinations of Cannabidiol and Δ(9)-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain
por: Sepulveda, Diana E., et al.
Publicado: (2022)

Individual and combined effects of cannabidiol and Δ(9)-tetrahydrocannabinol on striato-cortical connectivity in the human brain
por: Wall, Matthew B, et al.
Publicado: (2022)

A pilot clinical study of Δ(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
por: Guzmán, M, et al.
Publicado: (2006)

Hippocampal CB(1) receptors mediate the memory impairing effects of Δ(9)-tetrahydrocannabinol
por: Wise, Laura E., et al.
Publicado: (2009)

Default Mode Network in the Effects of Δ9-Tetrahydrocannabinol (THC) on Human Executive Function
por: Bossong, Matthijs G., et al.
Publicado: (2013)

Evaluation of Δ(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
por: Coskun, Zeynep Mine, et al.
Publicado: (2016)

A Systematic Review and Meta-Analysis of the In Vivo Haemodynamic Effects of Δ(9)-Tetrahydrocannabinol
por: Sultan, Salahaden R., et al.
Publicado: (2018)

Δ(9)-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats
por: Vella, Rebecca K., et al.
Publicado: (2017)

Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review
por: Poyatos, Lourdes, et al.
Publicado: (2020)

Δ(9)-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits
por: Taskar, Pranjal S., et al.
Publicado: (2019)

Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ(9)-Tetrahydrocannabinol
por: Breivogel, Chris S., et al.
Publicado: (2020)

Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol
por: Landucci, Elisa, et al.
Publicado: (2022)

Evaluation of the Possible Anticonvulsant Effect of Δ(9)-Tetrahydrocannabinolic Acid in Murine Seizure Models
por: Benson, Melissa J., et al.
Publicado: (2022)

A Critical Review of the Role of the Cannabinoid Compounds Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment
por: Jones, Éamon, et al.
Publicado: (2020)

Enrichment and identification of Δ(9)-Tetrahydrocannabinolic acid synthase from Pichia pastoris culture supernatants
por: Lange, Kerstin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fth8l9e9ob92orfnh1cbbfbq3k