Acute myeloid leukemia with variant t(8;10;21)

The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3–4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;...

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Autores principales: Bacova, Barbora, Sobotka, Jiri, Kacirkova, Petra, Rivnacova, Veronika, Karlova/Zubata, Ivana, Novak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489803/
https://www.ncbi.nlm.nih.gov/pubmed/36158314
http://dx.doi.org/10.1016/j.lrr.2022.100350
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author Bacova, Barbora
Sobotka, Jiri
Kacirkova, Petra
Rivnacova, Veronika
Karlova/Zubata, Ivana
Novak, Jan
author_facet Bacova, Barbora
Sobotka, Jiri
Kacirkova, Petra
Rivnacova, Veronika
Karlova/Zubata, Ivana
Novak, Jan
author_sort Bacova, Barbora
collection PubMed
description The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3–4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c-KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m(2)) and achieved long-lasting remission.
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spelling pubmed-94898032022-09-22 Acute myeloid leukemia with variant t(8;10;21) Bacova, Barbora Sobotka, Jiri Kacirkova, Petra Rivnacova, Veronika Karlova/Zubata, Ivana Novak, Jan Leuk Res Rep Article The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3–4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c-KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m(2)) and achieved long-lasting remission. Elsevier 2022-09-15 /pmc/articles/PMC9489803/ /pubmed/36158314 http://dx.doi.org/10.1016/j.lrr.2022.100350 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bacova, Barbora
Sobotka, Jiri
Kacirkova, Petra
Rivnacova, Veronika
Karlova/Zubata, Ivana
Novak, Jan
Acute myeloid leukemia with variant t(8;10;21)
title Acute myeloid leukemia with variant t(8;10;21)
title_full Acute myeloid leukemia with variant t(8;10;21)
title_fullStr Acute myeloid leukemia with variant t(8;10;21)
title_full_unstemmed Acute myeloid leukemia with variant t(8;10;21)
title_short Acute myeloid leukemia with variant t(8;10;21)
title_sort acute myeloid leukemia with variant t(8;10;21)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489803/
https://www.ncbi.nlm.nih.gov/pubmed/36158314
http://dx.doi.org/10.1016/j.lrr.2022.100350
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