Enhanced anti-glioma efficacy of doxorubicin with BRD4 PROTAC degrader using targeted nanoparticles

Current treatment of glioma is hampered due to the physical blood-brain barrier (BBB) and the resistance to traditional chemotherapeutic agents. Herein, we proposed a combined treatment strategy based on Cyclo (Arg-Gly-Asp-d-Phe-Lys) (cRGDfk) peptides-modified nanoparticle named cRGD-P in a self-ass...

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Detalles Bibliográficos
Autores principales: He, Yihong, Zan, Xin, Miao, Junming, Wang, Bilan, Wu, Yin, Shen, Yangmei, Chen, Xinchuan, Gou, Hongfeng, Zheng, Songping, Huang, Ning, Cheng, Yongzhong, Ju, Yan, Fu, Xianghui, Qian, Zhiyong, Zhou, Peizhi, Liu, Jiagang, Gao, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489811/
https://www.ncbi.nlm.nih.gov/pubmed/36157053
http://dx.doi.org/10.1016/j.mtbio.2022.100423

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