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Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis

The cause of idiopathic normal pressure hydrocephalus's (iNPH) clinical symptoms remains unclear. The cerebral cortex is the center of the brain and provides a structural basis for complex perception and motor function. This study aimed to explore the relationship between changes in cerebral co...

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Autores principales: Lv, Minrui, Yang, Xiaolin, Zhou, Xi, Chen, Jiakuan, Wei, Haihua, Du, Duanming, Lin, Hai, Xia, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489844/
https://www.ncbi.nlm.nih.gov/pubmed/36158963
http://dx.doi.org/10.3389/fneur.2022.922199
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author Lv, Minrui
Yang, Xiaolin
Zhou, Xi
Chen, Jiakuan
Wei, Haihua
Du, Duanming
Lin, Hai
Xia, Jun
author_facet Lv, Minrui
Yang, Xiaolin
Zhou, Xi
Chen, Jiakuan
Wei, Haihua
Du, Duanming
Lin, Hai
Xia, Jun
author_sort Lv, Minrui
collection PubMed
description The cause of idiopathic normal pressure hydrocephalus's (iNPH) clinical symptoms remains unclear. The cerebral cortex is the center of the brain and provides a structural basis for complex perception and motor function. This study aimed to explore the relationship between changes in cerebral cortex volume and clinical symptoms in patients with iNPH. This study included 21 iNPH patients and 20 normal aging (NA) controls. Voxel-based morphometry statistical results showed that, compared with NA, the gray matter volumes of patients with iNPH in the bilateral temporal lobe, bilateral hippocampus, bilateral thalamus, bilateral insula, left amygdala, right lenticular nucleus, right putamen, and cerebellum decreased, while the volumes of gray matter in the bilateral paracentral lobules, precuneus, bilateral supplementary motor area, medial side of the left cerebral hemisphere, and median cingulate and paracingulate gyri increased. Correlation analysis among the volumes of white matter and gray matter in the cerebrum and cerebellum and the iNPH grading scale (iNPHGS) revealed that the volume of white matter was negatively correlated with the iNPHGS (P < 0.05), while the gray matter volumes of cerebellar area 6 and area 8 were negatively correlated with the clinical symptoms of iNPH (P < 0.05). The volume of gray matter in the cerebellar vermis was negatively correlated with gait, and the gray matter volume of cerebellar area 6 was negatively correlated with cognition. Our findings suggest that the cerebellum also plays an important role in the pathogenesis of iNPH, potentially highlighting new research avenues for iNPH.
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spelling pubmed-94898442022-09-22 Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis Lv, Minrui Yang, Xiaolin Zhou, Xi Chen, Jiakuan Wei, Haihua Du, Duanming Lin, Hai Xia, Jun Front Neurol Neurology The cause of idiopathic normal pressure hydrocephalus's (iNPH) clinical symptoms remains unclear. The cerebral cortex is the center of the brain and provides a structural basis for complex perception and motor function. This study aimed to explore the relationship between changes in cerebral cortex volume and clinical symptoms in patients with iNPH. This study included 21 iNPH patients and 20 normal aging (NA) controls. Voxel-based morphometry statistical results showed that, compared with NA, the gray matter volumes of patients with iNPH in the bilateral temporal lobe, bilateral hippocampus, bilateral thalamus, bilateral insula, left amygdala, right lenticular nucleus, right putamen, and cerebellum decreased, while the volumes of gray matter in the bilateral paracentral lobules, precuneus, bilateral supplementary motor area, medial side of the left cerebral hemisphere, and median cingulate and paracingulate gyri increased. Correlation analysis among the volumes of white matter and gray matter in the cerebrum and cerebellum and the iNPH grading scale (iNPHGS) revealed that the volume of white matter was negatively correlated with the iNPHGS (P < 0.05), while the gray matter volumes of cerebellar area 6 and area 8 were negatively correlated with the clinical symptoms of iNPH (P < 0.05). The volume of gray matter in the cerebellar vermis was negatively correlated with gait, and the gray matter volume of cerebellar area 6 was negatively correlated with cognition. Our findings suggest that the cerebellum also plays an important role in the pathogenesis of iNPH, potentially highlighting new research avenues for iNPH. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9489844/ /pubmed/36158963 http://dx.doi.org/10.3389/fneur.2022.922199 Text en Copyright © 2022 Lv, Yang, Zhou, Chen, Wei, Du, Lin and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Lv, Minrui
Yang, Xiaolin
Zhou, Xi
Chen, Jiakuan
Wei, Haihua
Du, Duanming
Lin, Hai
Xia, Jun
Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title_full Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title_fullStr Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title_full_unstemmed Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title_short Gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: A cross-sectional analysis
title_sort gray matter volume of cerebellum associated with idiopathic normal pressure hydrocephalus: a cross-sectional analysis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489844/
https://www.ncbi.nlm.nih.gov/pubmed/36158963
http://dx.doi.org/10.3389/fneur.2022.922199
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