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Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review
Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic compli...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489888/ https://www.ncbi.nlm.nih.gov/pubmed/36172074 http://dx.doi.org/10.17179/excli2022-5073 |
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author | Stefanile, Annunziata Cellerino, Maria Koudriavtseva, Tatiana |
author_facet | Stefanile, Annunziata Cellerino, Maria Koudriavtseva, Tatiana |
author_sort | Stefanile, Annunziata |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena. |
format | Online Article Text |
id | pubmed-9489888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-94898882022-09-27 Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review Stefanile, Annunziata Cellerino, Maria Koudriavtseva, Tatiana EXCLI J Review Article Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena. Leibniz Research Centre for Working Environment and Human Factors 2022-06-30 /pmc/articles/PMC9489888/ /pubmed/36172074 http://dx.doi.org/10.17179/excli2022-5073 Text en Copyright © 2022 Stefanile et al. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Review Article Stefanile, Annunziata Cellerino, Maria Koudriavtseva, Tatiana Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title | Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title_full | Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title_fullStr | Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title_full_unstemmed | Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title_short | Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review |
title_sort | elevated risk of thrombotic manifestations of sars-cov-2 infection in cancer patients: a literature review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489888/ https://www.ncbi.nlm.nih.gov/pubmed/36172074 http://dx.doi.org/10.17179/excli2022-5073 |
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