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Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination

Viral respiratory tract infections exacerbate airway disease and facilitate life-threatening bacterial colonization in cystic fibrosis (CF). Annual influenza vaccination is recommended and vaccines against other common respiratory viruses may further reduce pulmonary morbidity risk. Enteroviruses ha...

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Autores principales: Stone, Virginia M., Utorova, Renata, Butrym, Marta, Sioofy-Khojine, Amir-Babak, Hankaniemi, Minna M., Ringqvist, Emma E., Blanter, Marfa, Parajuli, Anirudra, Pincikova, Terezia, Fischler, Björn, Karpati, Ferenc, Hytönen, Vesa P., Hyöty, Heikki, Hjelte, Lena, Flodström-Tullberg, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490033/
https://www.ncbi.nlm.nih.gov/pubmed/36157581
http://dx.doi.org/10.1016/j.isci.2022.105070
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author Stone, Virginia M.
Utorova, Renata
Butrym, Marta
Sioofy-Khojine, Amir-Babak
Hankaniemi, Minna M.
Ringqvist, Emma E.
Blanter, Marfa
Parajuli, Anirudra
Pincikova, Terezia
Fischler, Björn
Karpati, Ferenc
Hytönen, Vesa P.
Hyöty, Heikki
Hjelte, Lena
Flodström-Tullberg, Malin
author_facet Stone, Virginia M.
Utorova, Renata
Butrym, Marta
Sioofy-Khojine, Amir-Babak
Hankaniemi, Minna M.
Ringqvist, Emma E.
Blanter, Marfa
Parajuli, Anirudra
Pincikova, Terezia
Fischler, Björn
Karpati, Ferenc
Hytönen, Vesa P.
Hyöty, Heikki
Hjelte, Lena
Flodström-Tullberg, Malin
author_sort Stone, Virginia M.
collection PubMed
description Viral respiratory tract infections exacerbate airway disease and facilitate life-threatening bacterial colonization in cystic fibrosis (CF). Annual influenza vaccination is recommended and vaccines against other common respiratory viruses may further reduce pulmonary morbidity risk. Enteroviruses have been found in nasopharyngeal samples from CF patients experiencing pulmonary exacerbations. Using serology tests, we found that infections by a group of enteroviruses, Coxsackievirus Bs (CVBs), are prevalent in CF. We next showed that a CVB vaccine, currently undergoing clinical development, prevents infection and CVB-instigated lung damage in a murine model of CF. Finally, we demonstrate that individuals with CF have normal vaccine responses to a similar, commonly used enterovirus vaccine (inactivated poliovirus vaccine). Our study demonstrates that CVB infections are common in CF and provides experimental evidence indicating that CVB vaccines could be efficacious in the CF population. The role of CVB infections in contributing to pulmonary exacerbations in CF should be further studied.
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spelling pubmed-94900332022-09-22 Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination Stone, Virginia M. Utorova, Renata Butrym, Marta Sioofy-Khojine, Amir-Babak Hankaniemi, Minna M. Ringqvist, Emma E. Blanter, Marfa Parajuli, Anirudra Pincikova, Terezia Fischler, Björn Karpati, Ferenc Hytönen, Vesa P. Hyöty, Heikki Hjelte, Lena Flodström-Tullberg, Malin iScience Article Viral respiratory tract infections exacerbate airway disease and facilitate life-threatening bacterial colonization in cystic fibrosis (CF). Annual influenza vaccination is recommended and vaccines against other common respiratory viruses may further reduce pulmonary morbidity risk. Enteroviruses have been found in nasopharyngeal samples from CF patients experiencing pulmonary exacerbations. Using serology tests, we found that infections by a group of enteroviruses, Coxsackievirus Bs (CVBs), are prevalent in CF. We next showed that a CVB vaccine, currently undergoing clinical development, prevents infection and CVB-instigated lung damage in a murine model of CF. Finally, we demonstrate that individuals with CF have normal vaccine responses to a similar, commonly used enterovirus vaccine (inactivated poliovirus vaccine). Our study demonstrates that CVB infections are common in CF and provides experimental evidence indicating that CVB vaccines could be efficacious in the CF population. The role of CVB infections in contributing to pulmonary exacerbations in CF should be further studied. Elsevier 2022-09-05 /pmc/articles/PMC9490033/ /pubmed/36157581 http://dx.doi.org/10.1016/j.isci.2022.105070 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stone, Virginia M.
Utorova, Renata
Butrym, Marta
Sioofy-Khojine, Amir-Babak
Hankaniemi, Minna M.
Ringqvist, Emma E.
Blanter, Marfa
Parajuli, Anirudra
Pincikova, Terezia
Fischler, Björn
Karpati, Ferenc
Hytönen, Vesa P.
Hyöty, Heikki
Hjelte, Lena
Flodström-Tullberg, Malin
Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title_full Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title_fullStr Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title_full_unstemmed Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title_short Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
title_sort coxsackievirus b infections are common in cystic fibrosis and experimental evidence supports protection by vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490033/
https://www.ncbi.nlm.nih.gov/pubmed/36157581
http://dx.doi.org/10.1016/j.isci.2022.105070
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