Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A

The RET receptor tyrosine kinase plays a pivotal role in cell survival, proliferation, and differentiation, and its abnormal activation leads to cancers through receptor fusions or point mutations. Mutations that disrupt the disulfide network in the extracellular domain (ECD) of RET drive multiple e...

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Detalles Bibliográficos
Autores principales: Liu, Yixin, De Castro Ribeiro, Orquidea, Haapanen, Outi, Craven, Gregory B., Sharma, Vivek, Muench, Stephen P., Goldman, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490035/
https://www.ncbi.nlm.nih.gov/pubmed/35985422
http://dx.doi.org/10.1016/j.jbc.2022.102380

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