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The interplay between physical cues and mechanosensitive ion channels in cancer metastasis
Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490090/ https://www.ncbi.nlm.nih.gov/pubmed/36158191 http://dx.doi.org/10.3389/fcell.2022.954099 |
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author | Bera, Kaustav Kiepas, Alexander Zhang, Yuqi Sun, Sean X. Konstantopoulos, Konstantinos |
author_facet | Bera, Kaustav Kiepas, Alexander Zhang, Yuqi Sun, Sean X. Konstantopoulos, Konstantinos |
author_sort | Bera, Kaustav |
collection | PubMed |
description | Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ion channels (MICs) are especially important transducers of physical stimuli into biochemical signals. In this review, we describe how physical cues in the tumor microenvironment are sensed by MICs and contribute to cancer metastasis. First, we highlight mechanical perturbations, by both solid and fluid surroundings typically found in the tumor microenvironment and during critical stages of cancer cell dissemination from the primary tumor. Next, we describe how Piezo1/2 and transient receptor potential (TRP) channels respond to these physical cues to regulate cancer cell behavior during different stages of metastasis. We conclude by proposing alternative mechanisms of MIC activation that work in tandem with cytoskeletal components and other ion channels to bestow cells with the capacity to sense, respond and navigate through the surrounding microenvironment. Collectively, this review provides a perspective for devising treatment strategies against cancer by targeting MICs that sense aberrant physical characteristics during metastasis, the most lethal aspect of cancer. |
format | Online Article Text |
id | pubmed-9490090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94900902022-09-22 The interplay between physical cues and mechanosensitive ion channels in cancer metastasis Bera, Kaustav Kiepas, Alexander Zhang, Yuqi Sun, Sean X. Konstantopoulos, Konstantinos Front Cell Dev Biol Cell and Developmental Biology Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ion channels (MICs) are especially important transducers of physical stimuli into biochemical signals. In this review, we describe how physical cues in the tumor microenvironment are sensed by MICs and contribute to cancer metastasis. First, we highlight mechanical perturbations, by both solid and fluid surroundings typically found in the tumor microenvironment and during critical stages of cancer cell dissemination from the primary tumor. Next, we describe how Piezo1/2 and transient receptor potential (TRP) channels respond to these physical cues to regulate cancer cell behavior during different stages of metastasis. We conclude by proposing alternative mechanisms of MIC activation that work in tandem with cytoskeletal components and other ion channels to bestow cells with the capacity to sense, respond and navigate through the surrounding microenvironment. Collectively, this review provides a perspective for devising treatment strategies against cancer by targeting MICs that sense aberrant physical characteristics during metastasis, the most lethal aspect of cancer. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9490090/ /pubmed/36158191 http://dx.doi.org/10.3389/fcell.2022.954099 Text en Copyright © 2022 Bera, Kiepas, Zhang, Sun and Konstantopoulos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Bera, Kaustav Kiepas, Alexander Zhang, Yuqi Sun, Sean X. Konstantopoulos, Konstantinos The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title | The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title_full | The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title_fullStr | The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title_full_unstemmed | The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title_short | The interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
title_sort | interplay between physical cues and mechanosensitive ion channels in cancer metastasis |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490090/ https://www.ncbi.nlm.nih.gov/pubmed/36158191 http://dx.doi.org/10.3389/fcell.2022.954099 |
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