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Mitochondrial DNA mutations in ageing and cancer
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective groups of molecular hallmarks, and while some featu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490137/ https://www.ncbi.nlm.nih.gov/pubmed/35842901 http://dx.doi.org/10.1002/1878-0261.13291 |
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author | Smith, Anna L. M. Whitehall, Julia C. Greaves, Laura C. |
author_facet | Smith, Anna L. M. Whitehall, Julia C. Greaves, Laura C. |
author_sort | Smith, Anna L. M. |
collection | PubMed |
description | Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective groups of molecular hallmarks, and while some features are divergent between the two pathologies, several are shared. Perturbed mitochondrial function is one such common hallmark, and this observation therefore suggests that mitochondrial alterations may be of significance in age‐related cancer development. There is now considerable evidence documenting the accumulation of somatic mitochondrial DNA (mtDNA) mutations in ageing human postmitotic and replicative tissues. Similarly, mutations of the mitochondrial genome have been reported in human cancers for decades. The plethora of functions in which mitochondria partake, such as oxidative phosphorylation, redox balance, apoptosis and numerous biosynthetic pathways, manifests a variety of ways in which alterations in mtDNA may contribute to tumour growth. However, the specific mechanisms by which mtDNA mutations contribute to tumour progression remain elusive and often contradictory. This review aims to consolidate current knowledge and describe future direction within the field. |
format | Online Article Text |
id | pubmed-9490137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94901372022-09-30 Mitochondrial DNA mutations in ageing and cancer Smith, Anna L. M. Whitehall, Julia C. Greaves, Laura C. Mol Oncol Reviews Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective groups of molecular hallmarks, and while some features are divergent between the two pathologies, several are shared. Perturbed mitochondrial function is one such common hallmark, and this observation therefore suggests that mitochondrial alterations may be of significance in age‐related cancer development. There is now considerable evidence documenting the accumulation of somatic mitochondrial DNA (mtDNA) mutations in ageing human postmitotic and replicative tissues. Similarly, mutations of the mitochondrial genome have been reported in human cancers for decades. The plethora of functions in which mitochondria partake, such as oxidative phosphorylation, redox balance, apoptosis and numerous biosynthetic pathways, manifests a variety of ways in which alterations in mtDNA may contribute to tumour growth. However, the specific mechanisms by which mtDNA mutations contribute to tumour progression remain elusive and often contradictory. This review aims to consolidate current knowledge and describe future direction within the field. John Wiley and Sons Inc. 2022-07-28 2022-09 /pmc/articles/PMC9490137/ /pubmed/35842901 http://dx.doi.org/10.1002/1878-0261.13291 Text en © 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Smith, Anna L. M. Whitehall, Julia C. Greaves, Laura C. Mitochondrial DNA mutations in ageing and cancer |
title | Mitochondrial DNA mutations in ageing and cancer |
title_full | Mitochondrial DNA mutations in ageing and cancer |
title_fullStr | Mitochondrial DNA mutations in ageing and cancer |
title_full_unstemmed | Mitochondrial DNA mutations in ageing and cancer |
title_short | Mitochondrial DNA mutations in ageing and cancer |
title_sort | mitochondrial dna mutations in ageing and cancer |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490137/ https://www.ncbi.nlm.nih.gov/pubmed/35842901 http://dx.doi.org/10.1002/1878-0261.13291 |
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