Targeting cellular senescence to combat cancer and ageing

Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth factors. In this review, we summarize the context...

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Detalles Bibliográficos
Autores principales: Wang, Chen, Hao, Xue, Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490146/
https://www.ncbi.nlm.nih.gov/pubmed/35674055
http://dx.doi.org/10.1002/1878-0261.13266
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author Wang, Chen
Hao, Xue
Zhang, Rugang
author_facet Wang, Chen
Hao, Xue
Zhang, Rugang
author_sort Wang, Chen
collection PubMed
description Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth factors. In this review, we summarize the context‐dependent role of cellular senescence in ageing and in age‐related diseases, such as cancer. We discuss current approaches to targeting senescence to develop therapeutic strategies to combat cancer and to promote healthy ageing, and we outline our vision for future research directions for senescence‐based interventions in these fields.
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spelling pubmed-94901462022-09-30 Targeting cellular senescence to combat cancer and ageing Wang, Chen Hao, Xue Zhang, Rugang Mol Oncol Reviews Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth factors. In this review, we summarize the context‐dependent role of cellular senescence in ageing and in age‐related diseases, such as cancer. We discuss current approaches to targeting senescence to develop therapeutic strategies to combat cancer and to promote healthy ageing, and we outline our vision for future research directions for senescence‐based interventions in these fields. John Wiley and Sons Inc. 2022-06-20 2022-09 /pmc/articles/PMC9490146/ /pubmed/35674055 http://dx.doi.org/10.1002/1878-0261.13266 Text en © 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Wang, Chen
Hao, Xue
Zhang, Rugang
Targeting cellular senescence to combat cancer and ageing
title Targeting cellular senescence to combat cancer and ageing
title_full Targeting cellular senescence to combat cancer and ageing
title_fullStr Targeting cellular senescence to combat cancer and ageing
title_full_unstemmed Targeting cellular senescence to combat cancer and ageing
title_short Targeting cellular senescence to combat cancer and ageing
title_sort targeting cellular senescence to combat cancer and ageing
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490146/
https://www.ncbi.nlm.nih.gov/pubmed/35674055
http://dx.doi.org/10.1002/1878-0261.13266
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