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Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review

Bolbostemma paniculatum (Maxim.) Franquet is a unique species in China with a long history of medicinal use, which has the effects of detoxifying, dissolving lumps and dispersing swellings. And it is commonly used to treat many diseases, such as carbuncle and sore, acute mastitis, mammary cancer, sc...

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Autores principales: Zhou, Yujiao, Liu, Junyu, Zhang, Jianqiong, Xu, Yi, Li, Wangni, Gao, Pang, Xing, Yanghuan, Huang, Lehong, Qin, Xuhua, Jin, Shenrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490187/
https://www.ncbi.nlm.nih.gov/pubmed/36160391
http://dx.doi.org/10.3389/fphar.2022.974054
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author Zhou, Yujiao
Liu, Junyu
Zhang, Jianqiong
Xu, Yi
Li, Wangni
Gao, Pang
Xing, Yanghuan
Huang, Lehong
Qin, Xuhua
Jin, Shenrui
author_facet Zhou, Yujiao
Liu, Junyu
Zhang, Jianqiong
Xu, Yi
Li, Wangni
Gao, Pang
Xing, Yanghuan
Huang, Lehong
Qin, Xuhua
Jin, Shenrui
author_sort Zhou, Yujiao
collection PubMed
description Bolbostemma paniculatum (Maxim.) Franquet is a unique species in China with a long history of medicinal use, which has the effects of detoxifying, dissolving lumps and dispersing swellings. And it is commonly used to treat many diseases, such as carbuncle and sore, acute mastitis, mammary cancer, scrofula and subcutaneous nodule traditionally. Modern clinical studies have found that B. paniculatum and its compounds can be used for the treatment of a variety of cancers, mastitis, hyperplasia of mammary glands, chronic lymphadenitis, cervical lymph tuberculosis and surgical wart skin diseases, and the curative effect is positive. At present, a variety of Chinese patent medicines containing B. paniculatum have been exploited and marketed in China for the treatment of cancers, breast diseases and flat warts. This review article comprehensively discussed the traditional application, botany, chemical components, pharmacological activities, and quality control of B. paniculatum, put forward some noteworthy issues and suggestions in current studies, and briefly discussed the possible development potential of this plant as well as future research perspectives. 96 compounds have been isolated from B. paniculatum, including triterpenoids, sterols, alkaloids and other components, of which triterpenoid saponins are the main bioactive components. The crude extracts and monomer compounds of B. paniculatum have a wide range of pharmacological activities, such as anti-tumor, antiviral, anti-inflammatory, immunoregulatory, and so on. Moreover, its anti-tumor mechanism involves many aspects, including inhibiting cell proliferation, promoting cell apoptosis, blocking the cell cycle, interfering with cell invasion and metastasis, suppressing angiogenesis, and regulating autophagy. While there is a lack of systematic and in-depth research on its anti-tumor active components and mechanism of action at the moment; and a tight connection between the chemical composition and pharmacological activity of B. paniculatum has also not been established. Besides, a systematic quality determination standard for B. paniculatum should also be built, in order to carry out further research.
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spelling pubmed-94901872022-09-22 Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review Zhou, Yujiao Liu, Junyu Zhang, Jianqiong Xu, Yi Li, Wangni Gao, Pang Xing, Yanghuan Huang, Lehong Qin, Xuhua Jin, Shenrui Front Pharmacol Pharmacology Bolbostemma paniculatum (Maxim.) Franquet is a unique species in China with a long history of medicinal use, which has the effects of detoxifying, dissolving lumps and dispersing swellings. And it is commonly used to treat many diseases, such as carbuncle and sore, acute mastitis, mammary cancer, scrofula and subcutaneous nodule traditionally. Modern clinical studies have found that B. paniculatum and its compounds can be used for the treatment of a variety of cancers, mastitis, hyperplasia of mammary glands, chronic lymphadenitis, cervical lymph tuberculosis and surgical wart skin diseases, and the curative effect is positive. At present, a variety of Chinese patent medicines containing B. paniculatum have been exploited and marketed in China for the treatment of cancers, breast diseases and flat warts. This review article comprehensively discussed the traditional application, botany, chemical components, pharmacological activities, and quality control of B. paniculatum, put forward some noteworthy issues and suggestions in current studies, and briefly discussed the possible development potential of this plant as well as future research perspectives. 96 compounds have been isolated from B. paniculatum, including triterpenoids, sterols, alkaloids and other components, of which triterpenoid saponins are the main bioactive components. The crude extracts and monomer compounds of B. paniculatum have a wide range of pharmacological activities, such as anti-tumor, antiviral, anti-inflammatory, immunoregulatory, and so on. Moreover, its anti-tumor mechanism involves many aspects, including inhibiting cell proliferation, promoting cell apoptosis, blocking the cell cycle, interfering with cell invasion and metastasis, suppressing angiogenesis, and regulating autophagy. While there is a lack of systematic and in-depth research on its anti-tumor active components and mechanism of action at the moment; and a tight connection between the chemical composition and pharmacological activity of B. paniculatum has also not been established. Besides, a systematic quality determination standard for B. paniculatum should also be built, in order to carry out further research. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9490187/ /pubmed/36160391 http://dx.doi.org/10.3389/fphar.2022.974054 Text en Copyright © 2022 Zhou, Liu, Zhang, Xu, Li, Gao, Xing, Huang, Qin and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Yujiao
Liu, Junyu
Zhang, Jianqiong
Xu, Yi
Li, Wangni
Gao, Pang
Xing, Yanghuan
Huang, Lehong
Qin, Xuhua
Jin, Shenrui
Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title_full Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title_fullStr Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title_full_unstemmed Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title_short Chinese endemic medicinal plant Bolbostemma paniculatum (Maxim.) Franquet: A comprehensive review
title_sort chinese endemic medicinal plant bolbostemma paniculatum (maxim.) franquet: a comprehensive review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490187/
https://www.ncbi.nlm.nih.gov/pubmed/36160391
http://dx.doi.org/10.3389/fphar.2022.974054
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