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Pitx3 deficiency promotes age-dependent alterations in striatal medium spiny neurons

BACKGROUND: The classical motor symptoms of Parkinson’s disease (PD) are tightly linked to the gradual loss of dopamine within the striatum. Concomitantly, medium spiny neurons (MSNs) also experience morphological changes, such as reduced dendritic complexity and spine density, which may be potentia...

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Detalles Bibliográficos
Autores principales:	Chen, Xi, Yang, Zhaofei, Shao, Yaping, Kim, Kunhyok, Wang, Yuanyuan, Wang, Ying, Wu, Haifeng, Xu, Xiaolan, Le, Weidong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490232/ https://www.ncbi.nlm.nih.gov/pubmed/36158557 http://dx.doi.org/10.3389/fnagi.2022.960479

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