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Covalent fragment inhibits intramembrane proteolysis

Alzheimer’s disease (AD) is a serious public health crisis with only one current modifying treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been a leading approach in AD drug discovery and development. Despite the focus on GS inhibition, multiple GS inhibitors (GSIs) have f...

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Detalles Bibliográficos
Autores principales:	Eden, Angela, Zhao, Jing, Xiao, Yuanyuan, Gibson, James, Wang, Chunyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490316/ https://www.ncbi.nlm.nih.gov/pubmed/36158579 http://dx.doi.org/10.3389/fmolb.2022.958399

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