A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy

Globoid cell leukodystrophy (GLD), or Krabbe disease (KD) is a rare neurodegenerative disease, and adult-onset GLD is more even neglected by clinicians. This review provides detailed discussions of the serum enzymes, genes, clinical manifestations, neuroimaging features, and therapies of GLD, with p...

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Autores principales: Wu, Guode, Li, Zhenhua, Li, Jing, Li, Xin, Wang, Manxia, Zhang, Jing, Liu, Guangyao, Zhang, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490374/
https://www.ncbi.nlm.nih.gov/pubmed/36161165
http://dx.doi.org/10.3389/fnins.2022.998275
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author Wu, Guode
Li, Zhenhua
Li, Jing
Li, Xin
Wang, Manxia
Zhang, Jing
Liu, Guangyao
Zhang, Pengfei
author_facet Wu, Guode
Li, Zhenhua
Li, Jing
Li, Xin
Wang, Manxia
Zhang, Jing
Liu, Guangyao
Zhang, Pengfei
author_sort Wu, Guode
collection PubMed
description Globoid cell leukodystrophy (GLD), or Krabbe disease (KD) is a rare neurodegenerative disease, and adult-onset GLD is more even neglected by clinicians. This review provides detailed discussions of the serum enzymes, genes, clinical manifestations, neuroimaging features, and therapies of GLD, with particular emphasis on the characteristics of adult-onset GLD, in an attempt to provide clinicians with in-depth insights into this disease.
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spelling pubmed-94903742022-09-22 A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy Wu, Guode Li, Zhenhua Li, Jing Li, Xin Wang, Manxia Zhang, Jing Liu, Guangyao Zhang, Pengfei Front Neurosci Neuroscience Globoid cell leukodystrophy (GLD), or Krabbe disease (KD) is a rare neurodegenerative disease, and adult-onset GLD is more even neglected by clinicians. This review provides detailed discussions of the serum enzymes, genes, clinical manifestations, neuroimaging features, and therapies of GLD, with particular emphasis on the characteristics of adult-onset GLD, in an attempt to provide clinicians with in-depth insights into this disease. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9490374/ /pubmed/36161165 http://dx.doi.org/10.3389/fnins.2022.998275 Text en Copyright © 2022 Wu, Li, Li, Li, Wang, Zhang, Liu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wu, Guode
Li, Zhenhua
Li, Jing
Li, Xin
Wang, Manxia
Zhang, Jing
Liu, Guangyao
Zhang, Pengfei
A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title_full A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title_fullStr A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title_full_unstemmed A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title_short A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy
title_sort neglected neurodegenerative disease: adult-onset globoid cell leukodystrophy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490374/
https://www.ncbi.nlm.nih.gov/pubmed/36161165
http://dx.doi.org/10.3389/fnins.2022.998275
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