Uveal melanoma patient attitudes towards prognostic testing using gene expression profiling

AIM: This study explored uveal melanoma patient experiences and regret following molecular prognostic testing using a 15-gene expression profile (GEP) test. MATERIALS & METHODS: A retrospective, cross-sectional survey study was conducted through an online questionnaire capturing patient-reported...

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Detalles Bibliográficos
Autores principales: Williams, Basil K, Siegel, Jennifer J, Alsina, Katherina M, Johnston, Lauren, Sisco, Amanda, LiPira, Kyleigh, Selig, Sara M, Hovland, Peter G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490505/
https://www.ncbi.nlm.nih.gov/pubmed/36147875
http://dx.doi.org/10.2217/mmt-2022-0003
Descripción
Sumario:AIM: This study explored uveal melanoma patient experiences and regret following molecular prognostic testing using a 15-gene expression profile (GEP) test. MATERIALS & METHODS: A retrospective, cross-sectional survey study was conducted through an online questionnaire capturing patient-reported experiences with prognostic biopsy/molecular testing. RESULTS: Of 177 respondents, 159 (90%) wanted prognostic information at diagnosis. Most 15-GEP-tested patients who shared their results (99%) reported gaining value from testing, as did patients tested with other methods. Patients who received prognostic testing experienced lower decision regret than those who opted out. Decision regret did not differ based on GEP class. CONCLUSION: Most uveal melanoma patients desire prognostic testing and gain value from the GEP, independent of a high- or low-risk result.

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