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Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa
We report here on the transmission of HIV in a cohort of breastfeeding infants enrolled in a prevention of mother to child HIV transmission (PMTCT) programme at the epicentre of the HIV pandemic. South Africa implemented option B+ for PMTCT in 2015. Between 2013 and 2018, we enrolled 1219 infants bo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490562/ https://www.ncbi.nlm.nih.gov/pubmed/36130776 http://dx.doi.org/10.1136/bmjgh-2022-009927 |
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author | Daniels, Brodie Spooner, Elizabeth Coutsoudis, Anna |
author_facet | Daniels, Brodie Spooner, Elizabeth Coutsoudis, Anna |
author_sort | Daniels, Brodie |
collection | PubMed |
description | We report here on the transmission of HIV in a cohort of breastfeeding infants enrolled in a prevention of mother to child HIV transmission (PMTCT) programme at the epicentre of the HIV pandemic. South Africa implemented option B+ for PMTCT in 2015. Between 2013 and 2018, we enrolled 1219 infants born to HIV positive women into a non-inferiority trial assessing the current cotrimoxazole prophylaxis guidelines for HIV-exposed uninfected infants. Breastfeeding mothers and infants were enrolled and followed up at one of two clinics in eThekwini, KwaZulu-Natal, until 12 months of age. During the study period, 8 infants seroconverted (<1% transmission); these were likely four birth transmissions and four breastfeeding transmissions. It is critical in the post option B era to assess the reasons for vertical transmission of HIV to enable healthcare workers and policy makers to provide strategies to mitigate future infections. This report details the possible contributors to vertical transmission in this cohort and highlights the continued strategies that should be employed to further our goal towards reaching the elimination of mother to child HIV transmission |
format | Online Article Text |
id | pubmed-9490562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-94905622022-09-22 Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa Daniels, Brodie Spooner, Elizabeth Coutsoudis, Anna BMJ Glob Health Practice We report here on the transmission of HIV in a cohort of breastfeeding infants enrolled in a prevention of mother to child HIV transmission (PMTCT) programme at the epicentre of the HIV pandemic. South Africa implemented option B+ for PMTCT in 2015. Between 2013 and 2018, we enrolled 1219 infants born to HIV positive women into a non-inferiority trial assessing the current cotrimoxazole prophylaxis guidelines for HIV-exposed uninfected infants. Breastfeeding mothers and infants were enrolled and followed up at one of two clinics in eThekwini, KwaZulu-Natal, until 12 months of age. During the study period, 8 infants seroconverted (<1% transmission); these were likely four birth transmissions and four breastfeeding transmissions. It is critical in the post option B era to assess the reasons for vertical transmission of HIV to enable healthcare workers and policy makers to provide strategies to mitigate future infections. This report details the possible contributors to vertical transmission in this cohort and highlights the continued strategies that should be employed to further our goal towards reaching the elimination of mother to child HIV transmission BMJ Publishing Group 2022-09-20 /pmc/articles/PMC9490562/ /pubmed/36130776 http://dx.doi.org/10.1136/bmjgh-2022-009927 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Practice Daniels, Brodie Spooner, Elizabeth Coutsoudis, Anna Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title | Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title_full | Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title_fullStr | Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title_full_unstemmed | Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title_short | Getting to under 1% vertical HIV transmission: lessons from a breastfeeding cohort in South Africa |
title_sort | getting to under 1% vertical hiv transmission: lessons from a breastfeeding cohort in south africa |
topic | Practice |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490562/ https://www.ncbi.nlm.nih.gov/pubmed/36130776 http://dx.doi.org/10.1136/bmjgh-2022-009927 |
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