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Isothiourea-Catalyzed [2 + 2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins

[Image: see text] Enantioselective [2 + 2] cycloaddition of C(1)-ammonium enolates generated catalytically using the isothiourea HyperBTM with N-alkyl isatins gives spirocyclic β-lactones. In situ ring opening with an amine nucleophile generates isolable highly enantioenriched products in up to 92:8...

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Detalles Bibliográficos
Autores principales:	Abdelhamid, Yusra, Kasten, Kevin, Dunne, Joanne, Hartley, Will C., Young, Claire M., Cordes, David B., Slawin, Alexandra M. Z., Ng, Sean, Smith, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490795/ https://www.ncbi.nlm.nih.gov/pubmed/35848722 http://dx.doi.org/10.1021/acs.orglett.2c02170

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