Synthetic Approach toward Enantiopure Cyclic Sulfinamides

[Image: see text] A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S(N)2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtaine...

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Detalles Bibliográficos
Autores principales: Jersovs, Glebs, Bojars, Matiss, Donets, Pavel A., Suna, Edgars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490816/
https://www.ncbi.nlm.nih.gov/pubmed/35709471
http://dx.doi.org/10.1021/acs.orglett.2c01738
Descripción
Sumario:[Image: see text] A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S(N)2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral S(VI) derivatives such as sulfoximines and sulfonimidamides is demonstrated.

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