Synthetic Approach toward Enantiopure Cyclic Sulfinamides

[Image: see text] A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S(N)2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtaine...

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Autores principales: Jersovs, Glebs, Bojars, Matiss, Donets, Pavel A., Suna, Edgars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490816/
https://www.ncbi.nlm.nih.gov/pubmed/35709471
http://dx.doi.org/10.1021/acs.orglett.2c01738
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author Jersovs, Glebs
Bojars, Matiss
Donets, Pavel A.
Suna, Edgars
author_facet Jersovs, Glebs
Bojars, Matiss
Donets, Pavel A.
Suna, Edgars
author_sort Jersovs, Glebs
collection PubMed
description [Image: see text] A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S(N)2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral S(VI) derivatives such as sulfoximines and sulfonimidamides is demonstrated.
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spelling pubmed-94908162022-09-22 Synthetic Approach toward Enantiopure Cyclic Sulfinamides Jersovs, Glebs Bojars, Matiss Donets, Pavel A. Suna, Edgars Org Lett [Image: see text] A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S(N)2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral S(VI) derivatives such as sulfoximines and sulfonimidamides is demonstrated. American Chemical Society 2022-06-16 2022-07-01 /pmc/articles/PMC9490816/ /pubmed/35709471 http://dx.doi.org/10.1021/acs.orglett.2c01738 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Jersovs, Glebs
Bojars, Matiss
Donets, Pavel A.
Suna, Edgars
Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title_full Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title_fullStr Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title_full_unstemmed Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title_short Synthetic Approach toward Enantiopure Cyclic Sulfinamides
title_sort synthetic approach toward enantiopure cyclic sulfinamides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490816/
https://www.ncbi.nlm.nih.gov/pubmed/35709471
http://dx.doi.org/10.1021/acs.orglett.2c01738
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