Unexpected Isomerization of Oxetane-Carboxylic Acids

[Image: see text] Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these molecules, as this could dramatically affect the re...

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Autores principales: Chalyk, Bohdan, Grynyova, Anastasiia, Filimonova, Kateryna, Rudenko, Tymofii V., Dibchak, Dmitry, Mykhailiuk, Pavel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490830/
https://www.ncbi.nlm.nih.gov/pubmed/35766229
http://dx.doi.org/10.1021/acs.orglett.2c01402
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author Chalyk, Bohdan
Grynyova, Anastasiia
Filimonova, Kateryna
Rudenko, Tymofii V.
Dibchak, Dmitry
Mykhailiuk, Pavel K.
author_facet Chalyk, Bohdan
Grynyova, Anastasiia
Filimonova, Kateryna
Rudenko, Tymofii V.
Dibchak, Dmitry
Mykhailiuk, Pavel K.
author_sort Chalyk, Bohdan
collection PubMed
description [Image: see text] Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these molecules, as this could dramatically affect the reaction yields and lead to negative results (especially in those reactions that require heating).
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spelling pubmed-94908302022-09-22 Unexpected Isomerization of Oxetane-Carboxylic Acids Chalyk, Bohdan Grynyova, Anastasiia Filimonova, Kateryna Rudenko, Tymofii V. Dibchak, Dmitry Mykhailiuk, Pavel K. Org Lett [Image: see text] Many oxetane-carboxylic acids were found to be unstable. They easily isomerized into new (hetero)cyclic lactones while being stored at room temperature or slightly heated. Chemists should keep in mind the high instability of these molecules, as this could dramatically affect the reaction yields and lead to negative results (especially in those reactions that require heating). American Chemical Society 2022-06-29 2022-07-08 /pmc/articles/PMC9490830/ /pubmed/35766229 http://dx.doi.org/10.1021/acs.orglett.2c01402 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Chalyk, Bohdan
Grynyova, Anastasiia
Filimonova, Kateryna
Rudenko, Tymofii V.
Dibchak, Dmitry
Mykhailiuk, Pavel K.
Unexpected Isomerization of Oxetane-Carboxylic Acids
title Unexpected Isomerization of Oxetane-Carboxylic Acids
title_full Unexpected Isomerization of Oxetane-Carboxylic Acids
title_fullStr Unexpected Isomerization of Oxetane-Carboxylic Acids
title_full_unstemmed Unexpected Isomerization of Oxetane-Carboxylic Acids
title_short Unexpected Isomerization of Oxetane-Carboxylic Acids
title_sort unexpected isomerization of oxetane-carboxylic acids
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490830/
https://www.ncbi.nlm.nih.gov/pubmed/35766229
http://dx.doi.org/10.1021/acs.orglett.2c01402
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