Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways

BACKGROUND: DNA 5-hydroxymethylcytosine (5hmC) is produced by dynamic 5mC oxidation process contributing to tissue specification, and loss of 5hmC has been reported in multiple cancers including genitourinary cancers. However, 5hmC is also cell-type specific, and its variability may exist between di...

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Detalles Bibliográficos
Autores principales: Qi, Jie, Shi, Yue, Tan, Yezhen, Zhang, Qi, Zhang, Jianye, Wang, Jilu, Huang, Cong, Ci, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491006/
https://www.ncbi.nlm.nih.gov/pubmed/36127710
http://dx.doi.org/10.1186/s13148-022-01333-4

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