Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section

Endometrial stromal sarcomas (ESSs) account for approximately 0.2% of all uterine malignancies. Cellular leiomyoma (CL) often simulates low-grade ESS due to similar cytology. We report the case of a 34-year-old female with a mass per abdomen. Frozen sections showed a tumor with many thin- and thick-...

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Autores principales: Agarwal, Charu, Pujani, Mukta, Chauhan, Varsha, Chawla, Raina, Agarwal, Anu, Menia, Reetika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491063/
https://www.ncbi.nlm.nih.gov/pubmed/36158292
http://dx.doi.org/10.4103/GMIT.GMIT_53_20
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author Agarwal, Charu
Pujani, Mukta
Chauhan, Varsha
Chawla, Raina
Agarwal, Anu
Menia, Reetika
author_facet Agarwal, Charu
Pujani, Mukta
Chauhan, Varsha
Chawla, Raina
Agarwal, Anu
Menia, Reetika
author_sort Agarwal, Charu
collection PubMed
description Endometrial stromal sarcomas (ESSs) account for approximately 0.2% of all uterine malignancies. Cellular leiomyoma (CL) often simulates low-grade ESS due to similar cytology. We report the case of a 34-year-old female with a mass per abdomen. Frozen sections showed a tumor with many thin- and thick-walled vessels along with hyaline material. A differential diagnosis of CL and endometrial stromal tumor was suggested. The index case was diagnostically challenging to pathologists. Paraffin sections supplemented by immunohistochemistry (smooth muscle actin, CD10, and beta-catenin) favored CL. Frozen section sometimes leads to over/underestimation of tumor in view of small sampling area of tumor.
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spelling pubmed-94910632022-09-22 Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section Agarwal, Charu Pujani, Mukta Chauhan, Varsha Chawla, Raina Agarwal, Anu Menia, Reetika Gynecol Minim Invasive Ther Case Report Endometrial stromal sarcomas (ESSs) account for approximately 0.2% of all uterine malignancies. Cellular leiomyoma (CL) often simulates low-grade ESS due to similar cytology. We report the case of a 34-year-old female with a mass per abdomen. Frozen sections showed a tumor with many thin- and thick-walled vessels along with hyaline material. A differential diagnosis of CL and endometrial stromal tumor was suggested. The index case was diagnostically challenging to pathologists. Paraffin sections supplemented by immunohistochemistry (smooth muscle actin, CD10, and beta-catenin) favored CL. Frozen section sometimes leads to over/underestimation of tumor in view of small sampling area of tumor. Wolters Kluwer - Medknow 2022-08-05 /pmc/articles/PMC9491063/ /pubmed/36158292 http://dx.doi.org/10.4103/GMIT.GMIT_53_20 Text en Copyright: © 2022 Gynecology and Minimally Invasive Therapy https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Agarwal, Charu
Pujani, Mukta
Chauhan, Varsha
Chawla, Raina
Agarwal, Anu
Menia, Reetika
Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title_full Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title_fullStr Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title_full_unstemmed Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title_short Cellular Leiomyoma versus Endometrial Stromal Sarcoma: A Report of a Rare Case Presenting a Diagnostic Challenge on Intraoperative Frozen Section
title_sort cellular leiomyoma versus endometrial stromal sarcoma: a report of a rare case presenting a diagnostic challenge on intraoperative frozen section
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491063/
https://www.ncbi.nlm.nih.gov/pubmed/36158292
http://dx.doi.org/10.4103/GMIT.GMIT_53_20
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