Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

The integrated stress response (ISR) plays a pivotal role in adaptation of translation machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation mechanism involving reprogramming of translation via coordinated but independent actions of mTOR and plasma membrane amino acid...

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Detalles Bibliográficos
Autores principales: Krokowski, Dawid, Jobava, Raul, Szkop, Krzysztof J., Chen, Chien-Wen, Fu, Xu, Venus, Sarah, Guan, Bo-Jhih, Wu, Jing, Gao, Zhaofeng, Banaszuk, Wioleta, Tchorzewski, Marek, Mu, Tingwei, Ropelewski, Phil, Merrick, William C., Mao, Yuanhui, Sevval, Aksoylu Inci, Miranda, Helen, Qian, Shu-Bing, Manifava, Maria, Ktistakis, Nicholas T., Vourekas, Anastasios, Jankowsky, Eckhard, Topisirovic, Ivan, Larsson, Ola, Hatzoglou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491157/
https://www.ncbi.nlm.nih.gov/pubmed/35858571
http://dx.doi.org/10.1016/j.celrep.2022.111092

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