Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation

Herein we present a photocatalyst- and additive-free radical hydroacylation of electron-poor double bonds under mild reaction conditions. Using 4-acyl-Hantzsch ester radical reservoirs, various Michael acceptors, enones and para-quinone methide substrates could be used. The protocol enabled further...

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Autores principales: Pálvölgyi, Ádám Márk, Ehrschwendtner, Florian, Schnürch, Michael, Bica-Schröder, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491158/
https://www.ncbi.nlm.nih.gov/pubmed/36073152
http://dx.doi.org/10.1039/d2ob01364a
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author Pálvölgyi, Ádám Márk
Ehrschwendtner, Florian
Schnürch, Michael
Bica-Schröder, Katharina
author_facet Pálvölgyi, Ádám Márk
Ehrschwendtner, Florian
Schnürch, Michael
Bica-Schröder, Katharina
author_sort Pálvölgyi, Ádám Márk
collection PubMed
description Herein we present a photocatalyst- and additive-free radical hydroacylation of electron-poor double bonds under mild reaction conditions. Using 4-acyl-Hantzsch ester radical reservoirs, various Michael acceptors, enones and para-quinone methide substrates could be used. The protocol enabled further derivatizations and it could also be extended to a few unactivated alkenes. Moreover, the nature of the radical process was also investigated.
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spelling pubmed-94911582022-10-31 Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation Pálvölgyi, Ádám Márk Ehrschwendtner, Florian Schnürch, Michael Bica-Schröder, Katharina Org Biomol Chem Chemistry Herein we present a photocatalyst- and additive-free radical hydroacylation of electron-poor double bonds under mild reaction conditions. Using 4-acyl-Hantzsch ester radical reservoirs, various Michael acceptors, enones and para-quinone methide substrates could be used. The protocol enabled further derivatizations and it could also be extended to a few unactivated alkenes. Moreover, the nature of the radical process was also investigated. The Royal Society of Chemistry 2022-08-30 /pmc/articles/PMC9491158/ /pubmed/36073152 http://dx.doi.org/10.1039/d2ob01364a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pálvölgyi, Ádám Márk
Ehrschwendtner, Florian
Schnürch, Michael
Bica-Schröder, Katharina
Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title_full Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title_fullStr Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title_full_unstemmed Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title_short Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
title_sort photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491158/
https://www.ncbi.nlm.nih.gov/pubmed/36073152
http://dx.doi.org/10.1039/d2ob01364a
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AT schnurchmichael photocatalystfreehydroacylationsofelectronpooralkenesandenonesundervisiblelightirradiation
AT bicaschroderkatharina photocatalystfreehydroacylationsofelectronpooralkenesandenonesundervisiblelightirradiation

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