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Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis

Metabolic status and gut microecology are implicated in psoriasis. Methotrexate (MTX) is usually the first-line treatment for this disease. However, the relationship between MTX and host metabolic status and the gut microbiota is unclear. This study aimed to characterize the features of blood metabo...

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Autores principales: Qiu, Qinwei, Deng, Jingwen, Deng, Hao, Yao, Danni, Yan, Yuhong, Ye, Shuyan, Shang, Xiaoxiao, Deng, Yusheng, Han, Lijuan, Zheng, Guangjuan, Roy, Bhaskar, Chen, Yang, Han, Ling, Huang, Runyue, Fang, Xiaodong, Lu, Chuanjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491226/
https://www.ncbi.nlm.nih.gov/pubmed/36159864
http://dx.doi.org/10.3389/fimmu.2022.937539
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author Qiu, Qinwei
Deng, Jingwen
Deng, Hao
Yao, Danni
Yan, Yuhong
Ye, Shuyan
Shang, Xiaoxiao
Deng, Yusheng
Han, Lijuan
Zheng, Guangjuan
Roy, Bhaskar
Chen, Yang
Han, Ling
Huang, Runyue
Fang, Xiaodong
Lu, Chuanjian
author_facet Qiu, Qinwei
Deng, Jingwen
Deng, Hao
Yao, Danni
Yan, Yuhong
Ye, Shuyan
Shang, Xiaoxiao
Deng, Yusheng
Han, Lijuan
Zheng, Guangjuan
Roy, Bhaskar
Chen, Yang
Han, Ling
Huang, Runyue
Fang, Xiaodong
Lu, Chuanjian
author_sort Qiu, Qinwei
collection PubMed
description Metabolic status and gut microecology are implicated in psoriasis. Methotrexate (MTX) is usually the first-line treatment for this disease. However, the relationship between MTX and host metabolic status and the gut microbiota is unclear. This study aimed to characterize the features of blood metabolome and gut microbiome in patients with psoriasis after treatment with MTX. Serum and stool samples were collected from 15 patients with psoriasis. Untargeted liquid chromatography–mass spectrometry and metagenomics sequencing were applied to profile the blood metabolome and gut microbiome, respectively. We found that the response to MTX varied according to metabolomic and metagenomic features at baseline; for example, patients who had high levels of serum nutrient molecular and more enriched gut microbiota had a poor response. After 16 weeks of MTX, we observed a reduction in microbial activity pathways, and patients with a good response showed more microbial activity and less biosynthesis of serum fatty acid. We also found an association between the serum metabolome and the gut microbiome before intervention with MTX. Carbohydrate metabolism, transporter systems, and protein synthesis within microbes were associated with host metabolic clusters of lipids, benzenoids, and organic acids. These findings suggest that the metabolic status of the blood and the gut microbiome is involved in the effectiveness of MTX in psoriasis, and that inhibition of symbiotic intestinal microbiota may be one of the mechanisms of action of MTX. Prospective studies in larger sample sizes are needed to confirm these findings.
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spelling pubmed-94912262022-09-22 Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis Qiu, Qinwei Deng, Jingwen Deng, Hao Yao, Danni Yan, Yuhong Ye, Shuyan Shang, Xiaoxiao Deng, Yusheng Han, Lijuan Zheng, Guangjuan Roy, Bhaskar Chen, Yang Han, Ling Huang, Runyue Fang, Xiaodong Lu, Chuanjian Front Immunol Immunology Metabolic status and gut microecology are implicated in psoriasis. Methotrexate (MTX) is usually the first-line treatment for this disease. However, the relationship between MTX and host metabolic status and the gut microbiota is unclear. This study aimed to characterize the features of blood metabolome and gut microbiome in patients with psoriasis after treatment with MTX. Serum and stool samples were collected from 15 patients with psoriasis. Untargeted liquid chromatography–mass spectrometry and metagenomics sequencing were applied to profile the blood metabolome and gut microbiome, respectively. We found that the response to MTX varied according to metabolomic and metagenomic features at baseline; for example, patients who had high levels of serum nutrient molecular and more enriched gut microbiota had a poor response. After 16 weeks of MTX, we observed a reduction in microbial activity pathways, and patients with a good response showed more microbial activity and less biosynthesis of serum fatty acid. We also found an association between the serum metabolome and the gut microbiome before intervention with MTX. Carbohydrate metabolism, transporter systems, and protein synthesis within microbes were associated with host metabolic clusters of lipids, benzenoids, and organic acids. These findings suggest that the metabolic status of the blood and the gut microbiome is involved in the effectiveness of MTX in psoriasis, and that inhibition of symbiotic intestinal microbiota may be one of the mechanisms of action of MTX. Prospective studies in larger sample sizes are needed to confirm these findings. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9491226/ /pubmed/36159864 http://dx.doi.org/10.3389/fimmu.2022.937539 Text en Copyright © 2022 Qiu, Deng, Deng, Yao, Yan, Ye, Shang, Deng, Han, Zheng, Roy, Chen, Han, Huang, Fang and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Qiu, Qinwei
Deng, Jingwen
Deng, Hao
Yao, Danni
Yan, Yuhong
Ye, Shuyan
Shang, Xiaoxiao
Deng, Yusheng
Han, Lijuan
Zheng, Guangjuan
Roy, Bhaskar
Chen, Yang
Han, Ling
Huang, Runyue
Fang, Xiaodong
Lu, Chuanjian
Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title_full Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title_fullStr Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title_full_unstemmed Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title_short Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
title_sort association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491226/
https://www.ncbi.nlm.nih.gov/pubmed/36159864
http://dx.doi.org/10.3389/fimmu.2022.937539
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