Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis

Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and light-sheet imaging, we show that some fibroblast cells at the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically r...

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Detalles Bibliográficos
Autores principales: Wei, Xing, Zhang, Li, Zhang, Yiqun, Cooper, Cody, Brewer, Chris, Tsai, Chia-Feng, Wang, Yi-Ting, Glaz, Micah, Wessells, Hunter B., Que, Jianwen, Titus, Mark A., Cirulli, Vincenzino, Glaser, Adam, Liu, Tao, Reder, Nicholas P., Creighton, Chad J., Xin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491244/
https://www.ncbi.nlm.nih.gov/pubmed/36070687
http://dx.doi.org/10.1016/j.celrep.2022.111313

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