Cargando…
Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study
Focal seizures originating from the temporal lobe are commonly associated with peri‐ictal hypoxemia (PIH). During the course of temporal lobe seizures, epileptic discharges often not only spread within various parts of the temporal lobe but also possibly insula and frontal lobe. The link between spa...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491280/ https://www.ncbi.nlm.nih.gov/pubmed/35703584 http://dx.doi.org/10.1002/hbm.25975 |
_version_ | 1784793249947320320 |
---|---|
author | Jung, Julien Bouet, Romain Catenoix, Hélène Montavont, Alexandra Isnard, Jean Boulogne, Sébastien Guénot, Marc Ryvlin, Philippe Rheims, Sylvain |
author_facet | Jung, Julien Bouet, Romain Catenoix, Hélène Montavont, Alexandra Isnard, Jean Boulogne, Sébastien Guénot, Marc Ryvlin, Philippe Rheims, Sylvain |
author_sort | Jung, Julien |
collection | PubMed |
description | Focal seizures originating from the temporal lobe are commonly associated with peri‐ictal hypoxemia (PIH). During the course of temporal lobe seizures, epileptic discharges often not only spread within various parts of the temporal lobe but also possibly insula and frontal lobe. The link between spatial propagation of the seizure discharges and PIH is still unclear. The present study investigates the involvement of several brain structures including medial temporal structures, temporal pole, anterior insula, and frontal cortex in the occurrence of PIH. Using quantitative indices obtained during SEEG (stereoencephalography) recordings in 38 patients, we evaluated the epileptogenicity, the spatial propagation, and functional connectivity between those structures during seizures leading to PIH. Multivariate statistical analyses of SEEG quantitative indices showed that temporal lobe seizures leading to PIH are characterized by a strong involvement of amygdala and anterior insula during seizure propagation and a more widespread involvement of medial temporal lobe structures, lateral temporal lobe, temporal pole, and anterior cingulate at the end of the seizures. On the contrary, seizure‐onset zone was not associated with PIH occurrence. During seizure propagation, anterior insula, temporal pole, and temporal lateral neocortex activities were correlated with intensity of PIH. Lastly, PIH occurrence was also related to a widespread increase of synchrony between those structures. Those results suggest that PIH occurrence during temporal lobe seizures may be related to the activation of a widespread network of cortical structures, among which amygdala and anterior insula are key nodes. |
format | Online Article Text |
id | pubmed-9491280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94912802022-09-30 Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study Jung, Julien Bouet, Romain Catenoix, Hélène Montavont, Alexandra Isnard, Jean Boulogne, Sébastien Guénot, Marc Ryvlin, Philippe Rheims, Sylvain Hum Brain Mapp Research Articles Focal seizures originating from the temporal lobe are commonly associated with peri‐ictal hypoxemia (PIH). During the course of temporal lobe seizures, epileptic discharges often not only spread within various parts of the temporal lobe but also possibly insula and frontal lobe. The link between spatial propagation of the seizure discharges and PIH is still unclear. The present study investigates the involvement of several brain structures including medial temporal structures, temporal pole, anterior insula, and frontal cortex in the occurrence of PIH. Using quantitative indices obtained during SEEG (stereoencephalography) recordings in 38 patients, we evaluated the epileptogenicity, the spatial propagation, and functional connectivity between those structures during seizures leading to PIH. Multivariate statistical analyses of SEEG quantitative indices showed that temporal lobe seizures leading to PIH are characterized by a strong involvement of amygdala and anterior insula during seizure propagation and a more widespread involvement of medial temporal lobe structures, lateral temporal lobe, temporal pole, and anterior cingulate at the end of the seizures. On the contrary, seizure‐onset zone was not associated with PIH occurrence. During seizure propagation, anterior insula, temporal pole, and temporal lateral neocortex activities were correlated with intensity of PIH. Lastly, PIH occurrence was also related to a widespread increase of synchrony between those structures. Those results suggest that PIH occurrence during temporal lobe seizures may be related to the activation of a widespread network of cortical structures, among which amygdala and anterior insula are key nodes. John Wiley & Sons, Inc. 2022-06-15 /pmc/articles/PMC9491280/ /pubmed/35703584 http://dx.doi.org/10.1002/hbm.25975 Text en © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Jung, Julien Bouet, Romain Catenoix, Hélène Montavont, Alexandra Isnard, Jean Boulogne, Sébastien Guénot, Marc Ryvlin, Philippe Rheims, Sylvain Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title | Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title_full | Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title_fullStr | Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title_full_unstemmed | Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title_short | Peri‐ictal hypoxemia during temporal lobe seizures: A SEEG study |
title_sort | peri‐ictal hypoxemia during temporal lobe seizures: a seeg study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491280/ https://www.ncbi.nlm.nih.gov/pubmed/35703584 http://dx.doi.org/10.1002/hbm.25975 |
work_keys_str_mv | AT jungjulien periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT bouetromain periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT catenoixhelene periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT montavontalexandra periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT isnardjean periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT boulognesebastien periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT guenotmarc periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT ryvlinphilippe periictalhypoxemiaduringtemporallobeseizuresaseegstudy AT rheimssylvain periictalhypoxemiaduringtemporallobeseizuresaseegstudy |