Cargando…

An organometallic analogue of combretastatin A-4 and its apoptosis-inducing effects on lymphoma, leukemia and other tumor cells in vitro

Hexacarbonyl[1,3-dimethoxy-5-((4′-methoxyphenyl)ethynyl)benzene]dicobalt (NAHO27), an organometallic analogue of combretastatin A-4, has been synthesized and its activity against lymphoma, leukemia, breast cancer and melanoma cells has been investigated. It was shown that NAHO27 specifically induces...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abodo Onambele, Liliane, Hoffmann, Natalie, Kater, Lisa, Hemmersbach, Lars, Neudörfl, Jörg-Martin, Sitnikov, Nikolay, Kater, Benjamin, Frias, Corazon, Schmalz, Hans-Günther, Prokop, Aram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491352/ https://www.ncbi.nlm.nih.gov/pubmed/36320328 http://dx.doi.org/10.1039/d2md00144f

Ejemplares similares

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
por: Onambele, Liliane Abodo, et al.
Publicado: (2015)

Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden
por: Prinz, Christian, et al.
Publicado: (2015)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
por: Kater, Lisa, et al.
Publicado: (2021)

B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
por: Stein, Andreas, et al.
Publicado: (2022)

Novel indole-bearing combretastatin analogues as tubulin polymerization inhibitors
por: Kumar, Sunil, et al.
Publicado: (2013)

Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins
por: Lipeeva, Alla V., et al.
Publicado: (2014)

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
por: de Lima Neto, Jorge, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Water‐Soluble Esterase‐Activated CO‐Releasing Molecules Targeting Mitochondria
por: Hemmersbach, Lars, et al.
Publicado: (2022)

Dihydroxyquingdainone Induces Apoptosis in Leukaemia and Lymphoma Cells via the Mitochondrial Pathway in a Bcl-2- and Caspase-3-Dependent Manner and Overcomes Resistance to Cytostatic Drugs In Vitro
por: Baas, Jennifer, et al.
Publicado: (2022)

Head‐to‐Head Comparison of Selected Extra‐ and Intracellular CO‐Releasing Molecules on Their CO‐Releasing and Anti‐Inflammatory Properties
por: Li, Yingchun, et al.
Publicado: (2021)

(RS)-Tricarbonyl(η(4)-1,3-diacetoxy-5,5-dimethylcyclohexa-1,3-diene)iron(0)
por: Romanski, Steffen, et al.
Publicado: (2011)

Potassium (1-methoxycarbonyl-2-methylprop-2-en-2-ylidene)azinate
por: Reuter, Cédric, et al.
Publicado: (2010)

Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility
por: Chen, Zhi-Hao, et al.
Publicado: (2023)

Ruthenium Complex HB324 Induces Apoptosis via Mitochondrial Pathway with an Upregulation of Harakiri and Overcomes Cisplatin Resistance in Neuroblastoma Cells In Vitro
por: Wilke, Nicola L., et al.
Publicado: (2023)

Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues
por: do Amaral, Daniel Nascimento, et al.
Publicado: (2014)

trans-Ethylenedi-p-phenylene diacetate
por: Ritter, Stefanie, et al.
Publicado: (2009)

trans-1,2-Bis(3,5-dimethoxyphenyl)ethene
por: Ritter, Stefanie, et al.
Publicado: (2009)

Design, Synthesis, and Biological Evaluation of Novel Pyridine-Bridged Analogues of Combretastatin-A4 as Anticancer Agents
por: Zheng, Shilong, et al.
Publicado: (2014)

Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity
por: Ibrahim, Tarek S., et al.
Publicado: (2020)

Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents
por: Song, Ming-Yu, et al.
Publicado: (2020)

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues
por: Fayad, Eman, et al.
Publicado: (2023)

Enantioselective Total Synthesis and Structural Revision of Dysiherbol A
por: Baars, Julian, et al.
Publicado: (2021)

Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues
por: Wen, Zhiyong, et al.
Publicado: (2016)

3β-Acetoxy-19-hydroxy-Δ(5)-pregnen-20-one
por: Meier zu Greffen, Aike, et al.
Publicado: (2013)

ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates
por: Krause, Bernhard M., et al.
Publicado: (2021)

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4
por: Malebari, Azizah M., et al.
Publicado: (2021)

Synthesis of the 8,19‐Epoxysteroid Eurysterol A
por: Taspinar, Ömer, et al.
Publicado: (2020)

Organometallics
por: Bochmann, Manfred
Publicado: (1994)

Cytotoxicity Studies of Novel Combretastatin and Pterostilbene Derivatives
por: Jakubowska, Joanna, et al.
Publicado: (2014)

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies
por: Egharevba, Godshelp O., et al.
Publicado: (2022)

Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
por: Zaki, Islam, et al.
Publicado: (2022)

Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
por: Kelly, Patrick M., et al.
Publicado: (2017)

A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway
por: Hopff, Sina M., et al.
Publicado: (2021)

Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
por: Lanver, Andreas, et al.
Publicado: (2005)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Organometallic Chemistry
por: Spessard, Gary O
Publicado: (1997)

Organometallic chemistry
por: Straub, Bernd F, et al.
Publicado: (2016)

Tipping the balance: toward rational combination therapies to overcome venetoclax resistance in mantle cell lymphoma
por: Thus, Yvonne J., et al.
Publicado: (2022)

Comprehensive organometallic chemistry : the synthesis, reactions, and structures of organometallic compounds /
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_qg5mb2fne7bqo82d1gb2b02i4t