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Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women

Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12),...

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Autores principales: Silva-Reis, Anamei, Rodrigues Brandao-Rangel, Maysa Alves, Moraes-Ferreira, Renilson, Gonçalves-Alves, Thiago Gibson, Souza-Palmeira, Victor Hugo, Aquino-Santos, Helida Cristina, Bachi, Andre Luis Lacerda, de Oliveira, Luis Vicente Franco, Lopes-Martins, Rodrigo Álvaro Brandão, Oliveira-Silva, Iranse, Albertini, Regiane, Frison, Claudio Ricardo, Vieira, Rodolfo P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491379/
https://www.ncbi.nlm.nih.gov/pubmed/36160852
http://dx.doi.org/10.3389/fphys.2022.946402
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author Silva-Reis, Anamei
Rodrigues Brandao-Rangel, Maysa Alves
Moraes-Ferreira, Renilson
Gonçalves-Alves, Thiago Gibson
Souza-Palmeira, Victor Hugo
Aquino-Santos, Helida Cristina
Bachi, Andre Luis Lacerda
de Oliveira, Luis Vicente Franco
Lopes-Martins, Rodrigo Álvaro Brandão
Oliveira-Silva, Iranse
Albertini, Regiane
Frison, Claudio Ricardo
Vieira, Rodolfo P
author_facet Silva-Reis, Anamei
Rodrigues Brandao-Rangel, Maysa Alves
Moraes-Ferreira, Renilson
Gonçalves-Alves, Thiago Gibson
Souza-Palmeira, Victor Hugo
Aquino-Santos, Helida Cristina
Bachi, Andre Luis Lacerda
de Oliveira, Luis Vicente Franco
Lopes-Martins, Rodrigo Álvaro Brandão
Oliveira-Silva, Iranse
Albertini, Regiane
Frison, Claudio Ricardo
Vieira, Rodolfo P
author_sort Silva-Reis, Anamei
collection PubMed
description Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate. Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz–R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups. Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1.
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spelling pubmed-94913792022-09-22 Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women Silva-Reis, Anamei Rodrigues Brandao-Rangel, Maysa Alves Moraes-Ferreira, Renilson Gonçalves-Alves, Thiago Gibson Souza-Palmeira, Victor Hugo Aquino-Santos, Helida Cristina Bachi, Andre Luis Lacerda de Oliveira, Luis Vicente Franco Lopes-Martins, Rodrigo Álvaro Brandão Oliveira-Silva, Iranse Albertini, Regiane Frison, Claudio Ricardo Vieira, Rodolfo P Front Physiol Physiology Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate. Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz–R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups. Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1. Frontiers Media S.A. 2022-09-07 /pmc/articles/PMC9491379/ /pubmed/36160852 http://dx.doi.org/10.3389/fphys.2022.946402 Text en Copyright © 2022 Silva-Reis, Rodrigues Brandao-Rangel, Moraes-Ferreira, Gonçalves-Alves, Souza-Palmeira, Aquino-Santos, Bachi, Oliveira, Lopes-Martins, Oliveira-Silva, Albertini, Frison and Vieira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Silva-Reis, Anamei
Rodrigues Brandao-Rangel, Maysa Alves
Moraes-Ferreira, Renilson
Gonçalves-Alves, Thiago Gibson
Souza-Palmeira, Victor Hugo
Aquino-Santos, Helida Cristina
Bachi, Andre Luis Lacerda
de Oliveira, Luis Vicente Franco
Lopes-Martins, Rodrigo Álvaro Brandão
Oliveira-Silva, Iranse
Albertini, Regiane
Frison, Claudio Ricardo
Vieira, Rodolfo P
Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title_full Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title_fullStr Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title_full_unstemmed Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title_short Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
title_sort combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491379/
https://www.ncbi.nlm.nih.gov/pubmed/36160852
http://dx.doi.org/10.3389/fphys.2022.946402
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