Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography

E-cadherin adhesion is regulated at the cell surface, a process that can be replicated by activating antibodies. We use cryo-electron microscopy (EM) and X-ray crystallography to examine functional states of the cadherin adhesive dimer. This dimer is mediated by N-terminal beta strand-swapping invol...

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Detalles Bibliográficos
Autores principales: Maker, Allison, Bolejack, Madison, Schecterson, Leslayann, Hammerson, Brad, Abendroth, Jan, Edwards, Thomas E, Staker, Bart, Myler, Peter J, Gumbiner, Barry M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491697/
https://www.ncbi.nlm.nih.gov/pubmed/36157596
http://dx.doi.org/10.1093/pnasnexus/pgac163

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