PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

Severe COVID-19 is associated with hyperinflammation and weak T cell responses against SARS-CoV-2. However, the links between those processes remain partially characterized. Moreover, whether and how therapeutically manipulating T cells may benefit patients are unknown. Our genetic and pharmacologic...

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Detalles Bibliográficos
Autores principales: Duhalde Vega, Maite, Olivera, Daniela, Gastão Davanzo, Gustavo, Bertullo, Mauricio, Noya, Verónica, Fabiano de Souza, Gabriela, Primon Muraro, Stéfanie, Castro, Icaro, Arévalo, Ana Paula, Crispo, Martina, Galliussi, Germán, Russo, Sofía, Charbonnier, David, Rammauro, Florencia, Jeldres, Mathías, Alamón, Catalina, Varela, Valentina, Batthyany, Carlos, Bollati-Fogolín, Mariela, Oppezzo, Pablo, Pritsch, Otto, Proença-Módena, José Luiz, Nakaya, Helder I., Trias, Emiliano, Barbeito, Luis, Anegon, Ignacio, Cuturi, María Cristina, Moraes-Vieira, Pedro, Segovia, Mercedes, Hill, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491709/
https://www.ncbi.nlm.nih.gov/pubmed/36129987
http://dx.doi.org/10.1126/sciadv.abn6545

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