PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate kinase M2 (PKM2) promoted fibrosis progression by directly interacting with Smad7 and reinforcing transforming growth factor–...

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Detalles Bibliográficos
Autores principales: Gao, Shaoyan, Li, Xiaohe, Jiang, Qiuyan, Liang, Qing, Zhang, Fangxia, Li, Shuangling, Zhang, Ruiqin, Luan, Jiaoyan, Zhu, Jingyan, Gu, Xiaoting, Xiao, Ting, Huang, Hui, Chen, Shanshan, Ning, Wen, Yang, Guang, Yang, Cheng, Zhou, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491720/
https://www.ncbi.nlm.nih.gov/pubmed/36129984
http://dx.doi.org/10.1126/sciadv.abo0987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491720/
https://www.ncbi.nlm.nih.gov/pubmed/36129984
http://dx.doi.org/10.1126/sciadv.abo0987

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