The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells

Pancreatic β cell failure is a hallmark of diabetes. However, the causes of β cell failure remain incomplete. Here, we report the identification of tetranectin (TN), an adipose tissue–enriched secretory molecule, as a negative regulator of insulin secretion in β cells in diabetes. TN expression is s...

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Detalles Bibliográficos
Autores principales: Liu, Fen, Cai, Zixin, Yang, Yan, Plasko, George, Zhao, Piao, Wu, Xiangyue, Tang, Cheng, Li, Dandan, Li, Ting, Hu, Shanbiao, Song, Lei, Yu, Shaojie, Xu, Ran, Luo, Hairong, Fan, Libin, Wang, Ersong, Xiao, Zhen, Ji, Yujiao, Zeng, Rong, Li, Rongxia, Bai, Juli, Zhou, Zhiguang, Liu, Feng, Zhang, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491725/
https://www.ncbi.nlm.nih.gov/pubmed/36129988
http://dx.doi.org/10.1126/sciadv.abq1799

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