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Mechanistic insights into global suppressors of protein folding defects
Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such global suppressor mutations are key drivers of protein...
Autores principales: | Chattopadhyay, Gopinath, Bhowmick, Jayantika, Manjunath, Kavyashree, Ahmed, Shahbaz, Goyal, Parveen, Varadarajan, Raghavan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491731/ https://www.ncbi.nlm.nih.gov/pubmed/36037221 http://dx.doi.org/10.1371/journal.pgen.1010334 |
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