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Sustained vascular contractile response induced by an R- and S-epimer of the ergot alkaloid ergocristine and attenuation by a noncompetitive antagonist

Vasoconstriction is a known effect associated with ergot alkaloid consumption. The vascular contractile responses are often sustained for an extended period after exposure. Ergot alkaloids exist in two molecular configurations, the C-8-(R)-isomer (R-epimer) and the C-8-(S)-isomer (S-epimer). The sus...

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Detalles Bibliográficos
Autores principales: Cherewyk, Jensen E, Parker, Sarah E, Blakley, Barry R, Al-Dissi, Ahmad N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492154/
https://www.ncbi.nlm.nih.gov/pubmed/35775420
http://dx.doi.org/10.1093/jas/skac235

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