Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )

BACKGROUND: Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses. METHODS: For this observational study, we included participants who had receiv...

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Autores principales: De Pijper, Cornelis A, Langedijk, Annefleur C, Terryn, Sanne, Van Gucht, Steven, Grobusch, Martin P, Goorhuis, Abraham, Stijnis, Cornelis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492309/
https://www.ncbi.nlm.nih.gov/pubmed/33502530
http://dx.doi.org/10.1093/infdis/jiab034
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author De Pijper, Cornelis A
Langedijk, Annefleur C
Terryn, Sanne
Van Gucht, Steven
Grobusch, Martin P
Goorhuis, Abraham
Stijnis, Cornelis
author_facet De Pijper, Cornelis A
Langedijk, Annefleur C
Terryn, Sanne
Van Gucht, Steven
Grobusch, Martin P
Goorhuis, Abraham
Stijnis, Cornelis
author_sort De Pijper, Cornelis A
collection PubMed
description BACKGROUND: Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses. METHODS: For this observational study, we included participants who had received PrEP 10–24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster. RESULTS: All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen. CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10–24 years after PrEP.
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spelling pubmed-94923092022-09-22 Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( ) De Pijper, Cornelis A Langedijk, Annefleur C Terryn, Sanne Van Gucht, Steven Grobusch, Martin P Goorhuis, Abraham Stijnis, Cornelis J Infect Dis Brief Report BACKGROUND: Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses. METHODS: For this observational study, we included participants who had received PrEP 10–24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster. RESULTS: All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen. CONCLUSION: Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10–24 years after PrEP. Oxford University Press 2021-01-27 /pmc/articles/PMC9492309/ /pubmed/33502530 http://dx.doi.org/10.1093/infdis/jiab034 Text en © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
De Pijper, Cornelis A
Langedijk, Annefleur C
Terryn, Sanne
Van Gucht, Steven
Grobusch, Martin P
Goorhuis, Abraham
Stijnis, Cornelis
Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title_full Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title_fullStr Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title_full_unstemmed Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title_short Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization( )
title_sort long-term memory response after a single intramuscular rabies booster vaccination 10–24 years after primary immunization( )
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492309/
https://www.ncbi.nlm.nih.gov/pubmed/33502530
http://dx.doi.org/10.1093/infdis/jiab034
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