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Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis

Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasm...

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Detalles Bibliográficos
Autores principales: Wadayama, Tomoya, Shimizu, Mikito, Kimura, Ikko, Baba, Kousuke, Beck, Goichi, Nagano, Seiichi, Morita, Ryo, Nakagawa, Hidenori, Shirano, Michinori, Goto, Tetsushi, Norose, Kazumi, Hikosaka, Kenji, Murayama, Shigeo, Mochizuki, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492489/
https://www.ncbi.nlm.nih.gov/pubmed/35135916
http://dx.doi.org/10.2169/internalmedicine.8564-21
Descripción
Sumario:Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasma gondii nested polymerase chain reaction testing of cerebrospinal fluid. Since anti-Toxoplasma treatment proved completely ineffective, we presumed latent infection of the CNS with T. gondii. This case suggests the difficulty of distinguishing ECD with CNS involvement from toxoplasmic encephalitis and the possibility of a relationship between the pathogeneses of ECD and infection with T. gondii.