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Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis

Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasm...

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Autores principales: Wadayama, Tomoya, Shimizu, Mikito, Kimura, Ikko, Baba, Kousuke, Beck, Goichi, Nagano, Seiichi, Morita, Ryo, Nakagawa, Hidenori, Shirano, Michinori, Goto, Tetsushi, Norose, Kazumi, Hikosaka, Kenji, Murayama, Shigeo, Mochizuki, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492489/
https://www.ncbi.nlm.nih.gov/pubmed/35135916
http://dx.doi.org/10.2169/internalmedicine.8564-21
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author Wadayama, Tomoya
Shimizu, Mikito
Kimura, Ikko
Baba, Kousuke
Beck, Goichi
Nagano, Seiichi
Morita, Ryo
Nakagawa, Hidenori
Shirano, Michinori
Goto, Tetsushi
Norose, Kazumi
Hikosaka, Kenji
Murayama, Shigeo
Mochizuki, Hideki
author_facet Wadayama, Tomoya
Shimizu, Mikito
Kimura, Ikko
Baba, Kousuke
Beck, Goichi
Nagano, Seiichi
Morita, Ryo
Nakagawa, Hidenori
Shirano, Michinori
Goto, Tetsushi
Norose, Kazumi
Hikosaka, Kenji
Murayama, Shigeo
Mochizuki, Hideki
author_sort Wadayama, Tomoya
collection PubMed
description Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasma gondii nested polymerase chain reaction testing of cerebrospinal fluid. Since anti-Toxoplasma treatment proved completely ineffective, we presumed latent infection of the CNS with T. gondii. This case suggests the difficulty of distinguishing ECD with CNS involvement from toxoplasmic encephalitis and the possibility of a relationship between the pathogeneses of ECD and infection with T. gondii.
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spelling pubmed-94924892022-10-04 Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis Wadayama, Tomoya Shimizu, Mikito Kimura, Ikko Baba, Kousuke Beck, Goichi Nagano, Seiichi Morita, Ryo Nakagawa, Hidenori Shirano, Michinori Goto, Tetsushi Norose, Kazumi Hikosaka, Kenji Murayama, Shigeo Mochizuki, Hideki Intern Med Case Report Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasma gondii nested polymerase chain reaction testing of cerebrospinal fluid. Since anti-Toxoplasma treatment proved completely ineffective, we presumed latent infection of the CNS with T. gondii. This case suggests the difficulty of distinguishing ECD with CNS involvement from toxoplasmic encephalitis and the possibility of a relationship between the pathogeneses of ECD and infection with T. gondii. The Japanese Society of Internal Medicine 2022-02-08 2022-09-01 /pmc/articles/PMC9492489/ /pubmed/35135916 http://dx.doi.org/10.2169/internalmedicine.8564-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wadayama, Tomoya
Shimizu, Mikito
Kimura, Ikko
Baba, Kousuke
Beck, Goichi
Nagano, Seiichi
Morita, Ryo
Nakagawa, Hidenori
Shirano, Michinori
Goto, Tetsushi
Norose, Kazumi
Hikosaka, Kenji
Murayama, Shigeo
Mochizuki, Hideki
Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title_full Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title_fullStr Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title_full_unstemmed Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title_short Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
title_sort erdheim-chester disease involving the central nervous system with latent toxoplasmosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492489/
https://www.ncbi.nlm.nih.gov/pubmed/35135916
http://dx.doi.org/10.2169/internalmedicine.8564-21
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