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Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients

INTRODUCTION: Despite the advance in vaccination, the SARS-CoV-2 infection remains a challenge for the medical community. Outpatient and hospital therapy for COVID-19 are still improving. Our study aimed to report the results of a series of patients with COVID-19 who participated in an outpatient tr...

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Autores principales: Sobrinho, Silvestre, Perrone, Fabiana, Montal, Guilherme, Bacellar, Aroldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier España, S.L.U. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492515/
http://dx.doi.org/10.1016/j.mcpsp.2022.100346
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author Sobrinho, Silvestre
Perrone, Fabiana
Montal, Guilherme
Bacellar, Aroldo
author_facet Sobrinho, Silvestre
Perrone, Fabiana
Montal, Guilherme
Bacellar, Aroldo
author_sort Sobrinho, Silvestre
collection PubMed
description INTRODUCTION: Despite the advance in vaccination, the SARS-CoV-2 infection remains a challenge for the medical community. Outpatient and hospital therapy for COVID-19 are still improving. Our study aimed to report the results of a series of patients with COVID-19 who participated in an outpatient treatment protocol since the first clinical manifestation. METHODS: A case series report of individuals aged ≥ 18 years with clinical symptoms and a confirmed test for COVID-19 submitted to a treatment protocol. Patients were enrolled between May and September 2020 and followed for at least 15 days. The assessed clinical outcomes were the need for hospitalization, admission to the intensive care unit, orotracheal intubation, and death. RESULTS: We studied a 116 patients. The mean age was 48 ± 14 years. Females formed 53%. The main comorbidities wereobesity (15.5%), systemic arterial hypertension (10.3%) ,type II diabetes (6%), and lung diseases (6.0%). Temperature > 37.7 °C (51.7%), cough (55.2%), myalgia (37.1%), headache (37.9%), and fatigue (34.5%) were the most frequent signs and symptoms. According to different disease staging, the most administered drugs were: azithromycin, ivermectin, corticosteroid, antibiotics, and anticoagulants. There was no death, and hospitalization accounted for only 8.6% of the patients (1 in ICU); none required orotracheal intubation. The mean length of hospital stay was 5.8 days.
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spelling pubmed-94925152022-09-22 Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients Sobrinho, Silvestre Perrone, Fabiana Montal, Guilherme Bacellar, Aroldo Medicina Clínica Práctica Original INTRODUCTION: Despite the advance in vaccination, the SARS-CoV-2 infection remains a challenge for the medical community. Outpatient and hospital therapy for COVID-19 are still improving. Our study aimed to report the results of a series of patients with COVID-19 who participated in an outpatient treatment protocol since the first clinical manifestation. METHODS: A case series report of individuals aged ≥ 18 years with clinical symptoms and a confirmed test for COVID-19 submitted to a treatment protocol. Patients were enrolled between May and September 2020 and followed for at least 15 days. The assessed clinical outcomes were the need for hospitalization, admission to the intensive care unit, orotracheal intubation, and death. RESULTS: We studied a 116 patients. The mean age was 48 ± 14 years. Females formed 53%. The main comorbidities wereobesity (15.5%), systemic arterial hypertension (10.3%) ,type II diabetes (6%), and lung diseases (6.0%). Temperature > 37.7 °C (51.7%), cough (55.2%), myalgia (37.1%), headache (37.9%), and fatigue (34.5%) were the most frequent signs and symptoms. According to different disease staging, the most administered drugs were: azithromycin, ivermectin, corticosteroid, antibiotics, and anticoagulants. There was no death, and hospitalization accounted for only 8.6% of the patients (1 in ICU); none required orotracheal intubation. The mean length of hospital stay was 5.8 days. The Author(s). Published by Elsevier España, S.L.U. 2022 2022-09-22 /pmc/articles/PMC9492515/ http://dx.doi.org/10.1016/j.mcpsp.2022.100346 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original
Sobrinho, Silvestre
Perrone, Fabiana
Montal, Guilherme
Bacellar, Aroldo
Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title_full Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title_fullStr Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title_full_unstemmed Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title_short Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
title_sort clinical protocol for early treatment of covid-19 in a real-world scenario: results of a series of patients
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492515/
http://dx.doi.org/10.1016/j.mcpsp.2022.100346
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