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Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts
BACKGROUND: Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolesce...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492534/ https://www.ncbi.nlm.nih.gov/pubmed/35945263 http://dx.doi.org/10.1038/s41366-022-01202-3 |
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author | Silventoinen, Karri Li, Weilong Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Aaltonen, Sari Piirtola, Maarit Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Baker, Laura A. Tuvblad, Catherine Tynelius, Per Rasmussen, Finn Craig, Jeffrey M. Saffery, Richard Willemsen, Gonneke Bartels, Meike van Beijsterveldt, Catharina E. M. Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Lichtenstein, Paul Krueger, Robert F. McGue, Matt Pahlen, Shandell Christensen, Kaare Skytthe, Axel Kyvik, Kirsten O. Saudino, Kimberly J. Dubois, Lise Boivin, Michel Brendgen, Mara Dionne, Ginette Vitaro, Frank Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Corley, Robin P. Huibregtse, Brooke M. Knafo-Noam, Ariel Mankuta, David Abramson, Lior Haworth, Claire M. A. Plomin, Robert Bjerregaard-Andersen, Morten Beck-Nielsen, Henning Sodemann, Morten Duncan, Glen E. Buchwald, Dedra Burt, S. Alexandra Klump, Kelly L. Llewellyn, Clare H. Fisher, Abigail Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko |
author_facet | Silventoinen, Karri Li, Weilong Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Aaltonen, Sari Piirtola, Maarit Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Baker, Laura A. Tuvblad, Catherine Tynelius, Per Rasmussen, Finn Craig, Jeffrey M. Saffery, Richard Willemsen, Gonneke Bartels, Meike van Beijsterveldt, Catharina E. M. Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Lichtenstein, Paul Krueger, Robert F. McGue, Matt Pahlen, Shandell Christensen, Kaare Skytthe, Axel Kyvik, Kirsten O. Saudino, Kimberly J. Dubois, Lise Boivin, Michel Brendgen, Mara Dionne, Ginette Vitaro, Frank Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Corley, Robin P. Huibregtse, Brooke M. Knafo-Noam, Ariel Mankuta, David Abramson, Lior Haworth, Claire M. A. Plomin, Robert Bjerregaard-Andersen, Morten Beck-Nielsen, Henning Sodemann, Morten Duncan, Glen E. Buchwald, Dedra Burt, S. Alexandra Klump, Kelly L. Llewellyn, Clare H. Fisher, Abigail Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko |
author_sort | Silventoinen, Karri |
collection | PubMed |
description | BACKGROUND: Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. METHODS: We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. RESULTS: The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. CONCLUSIONS: Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity. |
format | Online Article Text |
id | pubmed-9492534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94925342022-09-23 Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts Silventoinen, Karri Li, Weilong Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Aaltonen, Sari Piirtola, Maarit Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Baker, Laura A. Tuvblad, Catherine Tynelius, Per Rasmussen, Finn Craig, Jeffrey M. Saffery, Richard Willemsen, Gonneke Bartels, Meike van Beijsterveldt, Catharina E. M. Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Lichtenstein, Paul Krueger, Robert F. McGue, Matt Pahlen, Shandell Christensen, Kaare Skytthe, Axel Kyvik, Kirsten O. Saudino, Kimberly J. Dubois, Lise Boivin, Michel Brendgen, Mara Dionne, Ginette Vitaro, Frank Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Corley, Robin P. Huibregtse, Brooke M. Knafo-Noam, Ariel Mankuta, David Abramson, Lior Haworth, Claire M. A. Plomin, Robert Bjerregaard-Andersen, Morten Beck-Nielsen, Henning Sodemann, Morten Duncan, Glen E. Buchwald, Dedra Burt, S. Alexandra Klump, Kelly L. Llewellyn, Clare H. Fisher, Abigail Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Int J Obes (Lond) Article BACKGROUND: Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. METHODS: We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. RESULTS: The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. CONCLUSIONS: Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity. Nature Publishing Group UK 2022-08-09 2022 /pmc/articles/PMC9492534/ /pubmed/35945263 http://dx.doi.org/10.1038/s41366-022-01202-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Silventoinen, Karri Li, Weilong Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Aaltonen, Sari Piirtola, Maarit Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Baker, Laura A. Tuvblad, Catherine Tynelius, Per Rasmussen, Finn Craig, Jeffrey M. Saffery, Richard Willemsen, Gonneke Bartels, Meike van Beijsterveldt, Catharina E. M. Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Lichtenstein, Paul Krueger, Robert F. McGue, Matt Pahlen, Shandell Christensen, Kaare Skytthe, Axel Kyvik, Kirsten O. Saudino, Kimberly J. Dubois, Lise Boivin, Michel Brendgen, Mara Dionne, Ginette Vitaro, Frank Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Corley, Robin P. Huibregtse, Brooke M. Knafo-Noam, Ariel Mankuta, David Abramson, Lior Haworth, Claire M. A. Plomin, Robert Bjerregaard-Andersen, Morten Beck-Nielsen, Henning Sodemann, Morten Duncan, Glen E. Buchwald, Dedra Burt, S. Alexandra Klump, Kelly L. Llewellyn, Clare H. Fisher, Abigail Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title | Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title_full | Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title_fullStr | Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title_full_unstemmed | Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title_short | Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
title_sort | changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492534/ https://www.ncbi.nlm.nih.gov/pubmed/35945263 http://dx.doi.org/10.1038/s41366-022-01202-3 |
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