Cargando…

Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals

OBJECTIVE: Obesity is complicated by inflammatory activation of the innate immune system. Stimulation of the calcium-sensing receptor (CaSR) by extra-cellular calcium ions ([Ca(2+)](ex)) can trigger NLRP3 inflammasome activation and inflammation. We hypothesised, that this mechanism might contribute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thrum, Stephan, Sommer, Miriam, Raulien, Nora, Gericke, Martin, Massier, Lucas, Kovacs, Peter, Krasselt, Marco, Landgraf, Kathrin, Körner, Antje, Dietrich, Arne, Blüher, Matthias, Rossol, Manuela, Wagner, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492543/ https://www.ncbi.nlm.nih.gov/pubmed/35931812 http://dx.doi.org/10.1038/s41366-022-01135-x

Ejemplares similares

Perturbation of the Monocyte Compartment in Human Obesity
por: Friedrich, Kathleen, et al.
Publicado: (2019)

Fatty Acid Oxidation Compensates for Lipopolysaccharide-Induced Warburg Effect in Glucose-Deprived Monocytes
por: Raulien, Nora, et al.
Publicado: (2017)

Extracellular Ca(2+) is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
por: Rossol, Manuela, et al.
Publicado: (2012)

CD56+ monocytes have a dysregulated cytokine response to lipopolysaccharide and accumulate in rheumatoid arthritis and immunosenescence
por: Krasselt, Marco, et al.
Publicado: (2013)

In vitro response pattern of monocytes after tmTNF reverse signaling predicts response to anti-TNF therapy in rheumatoid arthritis
por: Meusch, Undine, et al.
Publicado: (2015)

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis
por: Jäger, Elisabeth, et al.
Publicado: (2020)

FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?
por: Landgraf, Kathrin, et al.
Publicado: (2016)

Impaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases
por: Massier, Lucas, et al.
Publicado: (2021)

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children
por: Windholz, Jan, et al.
Publicado: (2011)

Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages
por: Lindhorst, Andreas, et al.
Publicado: (2021)

Direct Evidence of Brown Adipocytes in Different Fat Depots in Children
por: Rockstroh, Denise, et al.
Publicado: (2015)

Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
por: Murthy, Supriya, et al.
Publicado: (2022)

Circulating bacterial signature is linked to metabolic disease and shifts with metabolic alleviation after bariatric surgery
por: Chakaroun, Rima M., et al.
Publicado: (2021)

An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins
por: Krieg, Laura, et al.
Publicado: (2020)

TMEM18 is a regulator of adipogenesis and involved in PPARG signalling in vivo
por: Landgraf, Kathrin, et al.
Publicado: (2015)

Regulation of human adipogenesis by miR125b-5p
por: Rockstroh, Denise, et al.
Publicado: (2016)

OR07-01 Aberrant Expression Of Agouti Signaling Protein (ASIP) As A Cause of Monogenic Severe Childhood Obesity
por: Landgraf, Kathrin, et al.
Publicado: (2023)

Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated With Human Obesity
por: Böttcher, Yvonne, et al.
Publicado: (2009)

Influence of calcium on ceramide-1-phosphate monolayers
por: Oliveira, Joana S L, et al.
Publicado: (2016)

GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses
por: Quandt, Dagmar, et al.
Publicado: (2015)

Toll-Like Receptor 4 Is Involved in Inflammatory and Joint Destructive Pathways in Collagen-Induced Arthritis in DBA1J Mice
por: Pierer, Matthias, et al.
Publicado: (2011)

Brief Report: Deficient Thymic Output in Rheumatoid Arthritis Despite Abundance of Prethymic Progenitors
por: Wagner, Ulf, et al.
Publicado: (2013)

Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress
por: Griesser, Eva, et al.
Publicado: (2016)

ADCY5 Gene Expression in Adipose Tissue Is Related to Obesity in Men and Mice
por: Knigge, Anja, et al.
Publicado: (2015)

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance
por: Krieg, Laura, et al.
Publicado: (2022)

The Fabp4-Cre-Model is Insufficient to Study Hoxc9 Function in Adipose Tissue
por: Dommel, Sebastian, et al.
Publicado: (2020)

Influenza, Pneumococcal and Herpes Zoster Vaccination Rates in Patients with Autoimmune Inflammatory Rheumatic Diseases
por: Krasselt, Marco, et al.
Publicado: (2023)

Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity
por: Landgraf, Kathrin, et al.
Publicado: (2017)

Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition
por: Meusch, Undine, et al.
Publicado: (2013)

Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity
por: Schleinitz, Dorit, et al.
Publicado: (2011)

Sex-Specific Effects of the Genetic Variant rs10487505 Upstream of leptin in the Development of Obesity
por: Molder, Janine, et al.
Publicado: (2023)

COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children
por: Abdul Majeed, Sarah, et al.
Publicado: (2023)

Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity
por: Stanik, Juraj, et al.
Publicado: (2017)

The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis
por: Rossol, Manuela, et al.
Publicado: (2005)

Impact of Metabolic Regulators on the Expression of the Obesity Associated Genes FTO and NAMPT in Human Preadipocytes and Adipocytes
por: Friebe, Daniela, et al.
Publicado: (2011)

Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children
por: Hanschkow, Martha, et al.
Publicado: (2021)

Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?
por: Chakaroun, Rima M., et al.
Publicado: (2020)

Temperature sensing by the calcium-sensing receptor
por: Brennan, Sarah C., et al.
Publicado: (2023)

IL-10 Induced by mTNF Crosslinking-Mediated Reverse Signaling in a Whole Blood Assay Is Predictive of Response to TNFi Therapy in Rheumatoid Arthritis
por: Krasselt, Marco, et al.
Publicado: (2022)

Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis
por: Rossol, Manuela, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_r1qpspk0as5alir7qs7ivlms43