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Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality
BACKGROUND: The relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality. METHODS: We used longitu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492547/ https://www.ncbi.nlm.nih.gov/pubmed/35915134 http://dx.doi.org/10.1038/s41366-022-01195-z |
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author | Ahmadi, Matthew N. Lee, I-Min Hamer, Mark del Pozo Cruz, Borja Chen, Li Jung Eroglu, Elif Lai, Yun-Ju Ku, Po Wen Stamatakis, Emmanuel |
author_facet | Ahmadi, Matthew N. Lee, I-Min Hamer, Mark del Pozo Cruz, Borja Chen, Li Jung Eroglu, Elif Lai, Yun-Ju Ku, Po Wen Stamatakis, Emmanuel |
author_sort | Ahmadi, Matthew N. |
collection | PubMed |
description | BACKGROUND: The relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality. METHODS: We used longitudinal data from Taiwan’s MJ Cohort, comprising 116,228 general population adults recruited from 1998-2013 with repeated measures 4.6 y (2.5) apart and followed up for mortality for 11.9 y (3.5). Physical activity, body mass index (BMI), waist circumference (WC), and body fat percentage (BF%) groups and changes were based on public health and clinical guidelines. RESULTS: Compared to stable-insufficient physical activity, increasing physical activity from any baseline level was associated with lower ACM (HR [95%CI]): 0.85 [0.74, 0.96]) and CVD mortality (0.72 [0.55, 0.93]) risk. This was approximately equal to meeting physical activity guidelines at both timepoints (eg: 0.71 [0.58, 0.88] for CVD mortality). Compared to stable-overweight/moderate adiposity, decreasing adiposity level attenuated but did not offset mortality risk for all three outcomes (eg: BMI = 0.95 [0.76, 1.16] for CVD mortality). Only maintaining a healthy adiposity level at both timepoints offset mortality risk (BMI = 0.75 [0.61, 0.89]) for CVD mortality). In the joint changes analyses, lower mortality risk was a consequence of increases in physical activity across adiposity change groups (eg: WC decrease = 0.57 [0.48, 0.67]; WC stability = 0.73 [0.66, 0.80], WC increase = 0.83 [0.72, 0.97] for ACM). Decreasing adiposity attenuated the negative associations of decreased physical activity (BF% = 1.13 [0.95, 1.35] for ACM). CONCLUSIONS: We found a lower risk for ACM, CVD, and cancer mortality from increasing physical activity and an attenuation from decreasing adiposity regardless of baseline levels. The beneficial associations of joint changes were primarily driven by physical activity, suggesting lower mortality risk may be more immediate through physical activity improvements compared to adiposity improvements alone. |
format | Online Article Text |
id | pubmed-9492547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94925472022-09-23 Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality Ahmadi, Matthew N. Lee, I-Min Hamer, Mark del Pozo Cruz, Borja Chen, Li Jung Eroglu, Elif Lai, Yun-Ju Ku, Po Wen Stamatakis, Emmanuel Int J Obes (Lond) Article BACKGROUND: The relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality. METHODS: We used longitudinal data from Taiwan’s MJ Cohort, comprising 116,228 general population adults recruited from 1998-2013 with repeated measures 4.6 y (2.5) apart and followed up for mortality for 11.9 y (3.5). Physical activity, body mass index (BMI), waist circumference (WC), and body fat percentage (BF%) groups and changes were based on public health and clinical guidelines. RESULTS: Compared to stable-insufficient physical activity, increasing physical activity from any baseline level was associated with lower ACM (HR [95%CI]): 0.85 [0.74, 0.96]) and CVD mortality (0.72 [0.55, 0.93]) risk. This was approximately equal to meeting physical activity guidelines at both timepoints (eg: 0.71 [0.58, 0.88] for CVD mortality). Compared to stable-overweight/moderate adiposity, decreasing adiposity level attenuated but did not offset mortality risk for all three outcomes (eg: BMI = 0.95 [0.76, 1.16] for CVD mortality). Only maintaining a healthy adiposity level at both timepoints offset mortality risk (BMI = 0.75 [0.61, 0.89]) for CVD mortality). In the joint changes analyses, lower mortality risk was a consequence of increases in physical activity across adiposity change groups (eg: WC decrease = 0.57 [0.48, 0.67]; WC stability = 0.73 [0.66, 0.80], WC increase = 0.83 [0.72, 0.97] for ACM). Decreasing adiposity attenuated the negative associations of decreased physical activity (BF% = 1.13 [0.95, 1.35] for ACM). CONCLUSIONS: We found a lower risk for ACM, CVD, and cancer mortality from increasing physical activity and an attenuation from decreasing adiposity regardless of baseline levels. The beneficial associations of joint changes were primarily driven by physical activity, suggesting lower mortality risk may be more immediate through physical activity improvements compared to adiposity improvements alone. Nature Publishing Group UK 2022-08-01 2022 /pmc/articles/PMC9492547/ /pubmed/35915134 http://dx.doi.org/10.1038/s41366-022-01195-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ahmadi, Matthew N. Lee, I-Min Hamer, Mark del Pozo Cruz, Borja Chen, Li Jung Eroglu, Elif Lai, Yun-Ju Ku, Po Wen Stamatakis, Emmanuel Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title | Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title_full | Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title_fullStr | Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title_full_unstemmed | Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title_short | Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
title_sort | changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492547/ https://www.ncbi.nlm.nih.gov/pubmed/35915134 http://dx.doi.org/10.1038/s41366-022-01195-z |
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