Cargando…
A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells
An efficient strategy for cancer therapy is presented, in which a tumor mass is initially pretreated with calcium hydroxide, then treated with Taxotere (TXT). In this regard, an advanced delivery system based on iron oxide nanoparticles has been designed. The surface of nanoparticles was functionali...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492675/ https://www.ncbi.nlm.nih.gov/pubmed/36130999 http://dx.doi.org/10.1038/s42003-022-03966-w |
_version_ | 1784793529995755520 |
---|---|
author | Taheri-Ledari, Reza Zolfaghari, Ehsan Zarei-Shokat, Simindokht Kashtiaray, Amir Maleki, Ali |
author_facet | Taheri-Ledari, Reza Zolfaghari, Ehsan Zarei-Shokat, Simindokht Kashtiaray, Amir Maleki, Ali |
author_sort | Taheri-Ledari, Reza |
collection | PubMed |
description | An efficient strategy for cancer therapy is presented, in which a tumor mass is initially pretreated with calcium hydroxide, then treated with Taxotere (TXT). In this regard, an advanced delivery system based on iron oxide nanoparticles has been designed. The surface of nanoparticles was functionalized with sortilin (SORT-1, a human IgG1 monoclonal antibody) that specifically encodes caov-4 ovarian cancerous cells. Plasmonic heating of the incorporated gold nanoparticles in polyvinyl alcohol (PVA) has been exploited to control the release process of TXT. The in vitro, ex vivo and in vivo experiments have exhibited high efficacy of a seven-day pretreatment by Ca(OH)(2) plus 14 days treatment program by Ca(OH)(2)@Fe(3)O(4)/PVA/Au-SORT nano-therapeutics, where more penetration ratio resulted in tumor growth inhibition by ca. 78.3%. As a result, due to showing high values of the anti-tumor properties and biosafety, the presented pretreatment strategy is suggested for more effective treatment on the aged tumors. |
format | Online Article Text |
id | pubmed-9492675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-94926752022-09-23 A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells Taheri-Ledari, Reza Zolfaghari, Ehsan Zarei-Shokat, Simindokht Kashtiaray, Amir Maleki, Ali Commun Biol Article An efficient strategy for cancer therapy is presented, in which a tumor mass is initially pretreated with calcium hydroxide, then treated with Taxotere (TXT). In this regard, an advanced delivery system based on iron oxide nanoparticles has been designed. The surface of nanoparticles was functionalized with sortilin (SORT-1, a human IgG1 monoclonal antibody) that specifically encodes caov-4 ovarian cancerous cells. Plasmonic heating of the incorporated gold nanoparticles in polyvinyl alcohol (PVA) has been exploited to control the release process of TXT. The in vitro, ex vivo and in vivo experiments have exhibited high efficacy of a seven-day pretreatment by Ca(OH)(2) plus 14 days treatment program by Ca(OH)(2)@Fe(3)O(4)/PVA/Au-SORT nano-therapeutics, where more penetration ratio resulted in tumor growth inhibition by ca. 78.3%. As a result, due to showing high values of the anti-tumor properties and biosafety, the presented pretreatment strategy is suggested for more effective treatment on the aged tumors. Nature Publishing Group UK 2022-09-21 /pmc/articles/PMC9492675/ /pubmed/36130999 http://dx.doi.org/10.1038/s42003-022-03966-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Taheri-Ledari, Reza Zolfaghari, Ehsan Zarei-Shokat, Simindokht Kashtiaray, Amir Maleki, Ali A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title | A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title_full | A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title_fullStr | A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title_full_unstemmed | A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title_short | A magnetic antibody-conjugated nano-system for selective delivery of Ca(OH)(2) and taxotere in ovarian cancer cells |
title_sort | magnetic antibody-conjugated nano-system for selective delivery of ca(oh)(2) and taxotere in ovarian cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492675/ https://www.ncbi.nlm.nih.gov/pubmed/36130999 http://dx.doi.org/10.1038/s42003-022-03966-w |
work_keys_str_mv | AT taheriledarireza amagneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT zolfaghariehsan amagneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT zareishokatsimindokht amagneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT kashtiarayamir amagneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT malekiali amagneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT taheriledarireza magneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT zolfaghariehsan magneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT zareishokatsimindokht magneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT kashtiarayamir magneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells AT malekiali magneticantibodyconjugatednanosystemforselectivedeliveryofcaoh2andtaxotereinovariancancercells |