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Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms

Major Depression and Bipolar Disorder Type I (BIP-I) and Type II (BIP-II), are characterized by depressed, manic, and hypomanic episodes in which specific changes of physical activity, circadian rhythm, and sleep are observed. It is known that genetic factors contribute to variation in mood disorder...

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Autores principales: Sirignano, Lea, Streit, Fabian, Frank, Josef, Zillich, Lea, Witt, Stephanie H., Rietschel, Marcella, Foo, Jerome C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492698/
https://www.ncbi.nlm.nih.gov/pubmed/36131119
http://dx.doi.org/10.1038/s41598-022-19720-5
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author Sirignano, Lea
Streit, Fabian
Frank, Josef
Zillich, Lea
Witt, Stephanie H.
Rietschel, Marcella
Foo, Jerome C.
author_facet Sirignano, Lea
Streit, Fabian
Frank, Josef
Zillich, Lea
Witt, Stephanie H.
Rietschel, Marcella
Foo, Jerome C.
author_sort Sirignano, Lea
collection PubMed
description Major Depression and Bipolar Disorder Type I (BIP-I) and Type II (BIP-II), are characterized by depressed, manic, and hypomanic episodes in which specific changes of physical activity, circadian rhythm, and sleep are observed. It is known that genetic factors contribute to variation in mood disorders and biological rhythms, but unclear to what extent there is an overlap between their underlying genetics. In the present study, data from genome-wide association studies were used to examine the genetic relationship between mood disorders and biological rhythms. We tested the genetic correlation of depression, BIP-I, and BIP-II with physical activity (overall physical activity, moderate activity, sedentary behaviour), circadian rhythm (relative amplitude), and sleep features (sleep duration, daytime sleepiness). Genetic correlations of depression, BIP-I, and BIP-II with biological rhythms were compared to discover commonalities and differences. A gene-based analysis tested for associations of single genes and common circadian genes with mood disorders. Depression was negatively correlated with overall physical activity and positively with sedentary behaviour, while BIP-I showed associations in the opposite direction. Depression and BIP-II had negative correlations with relative amplitude. All mood disorders were positively correlated with daytime sleepiness. Overall, we observed both genetic commonalities and differences across mood disorders in their relationships with biological rhythms: depression and BIP-I differed the most, while BIP-II was in an intermediate position. Gene-based analysis suggested potential targets for further investigation. The present results suggest shared genetic underpinnings for the clinically observed associations between mood disorders and biological rhythms. Research considering possible joint mechanisms may offer avenues for improving disease detection and treatment.
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spelling pubmed-94926982022-09-23 Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms Sirignano, Lea Streit, Fabian Frank, Josef Zillich, Lea Witt, Stephanie H. Rietschel, Marcella Foo, Jerome C. Sci Rep Article Major Depression and Bipolar Disorder Type I (BIP-I) and Type II (BIP-II), are characterized by depressed, manic, and hypomanic episodes in which specific changes of physical activity, circadian rhythm, and sleep are observed. It is known that genetic factors contribute to variation in mood disorders and biological rhythms, but unclear to what extent there is an overlap between their underlying genetics. In the present study, data from genome-wide association studies were used to examine the genetic relationship between mood disorders and biological rhythms. We tested the genetic correlation of depression, BIP-I, and BIP-II with physical activity (overall physical activity, moderate activity, sedentary behaviour), circadian rhythm (relative amplitude), and sleep features (sleep duration, daytime sleepiness). Genetic correlations of depression, BIP-I, and BIP-II with biological rhythms were compared to discover commonalities and differences. A gene-based analysis tested for associations of single genes and common circadian genes with mood disorders. Depression was negatively correlated with overall physical activity and positively with sedentary behaviour, while BIP-I showed associations in the opposite direction. Depression and BIP-II had negative correlations with relative amplitude. All mood disorders were positively correlated with daytime sleepiness. Overall, we observed both genetic commonalities and differences across mood disorders in their relationships with biological rhythms: depression and BIP-I differed the most, while BIP-II was in an intermediate position. Gene-based analysis suggested potential targets for further investigation. The present results suggest shared genetic underpinnings for the clinically observed associations between mood disorders and biological rhythms. Research considering possible joint mechanisms may offer avenues for improving disease detection and treatment. Nature Publishing Group UK 2022-09-21 /pmc/articles/PMC9492698/ /pubmed/36131119 http://dx.doi.org/10.1038/s41598-022-19720-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sirignano, Lea
Streit, Fabian
Frank, Josef
Zillich, Lea
Witt, Stephanie H.
Rietschel, Marcella
Foo, Jerome C.
Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title_full Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title_fullStr Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title_full_unstemmed Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title_short Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
title_sort depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492698/
https://www.ncbi.nlm.nih.gov/pubmed/36131119
http://dx.doi.org/10.1038/s41598-022-19720-5
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