Cargando…
Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose
A tool was constructed to assess need of an oral glucose tolerance test (OGTT) in patients whose fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are normal. Data was collected from the longitudinal REACTION study conducted from June to November 2011 (14,686 subjects, aged ≥ 40 y). In people...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492843/ https://www.ncbi.nlm.nih.gov/pubmed/36157464 http://dx.doi.org/10.3389/fendo.2022.943750 |
_version_ | 1784793564713058304 |
---|---|
author | Sun, Kan Xiao, Xianchao You, Lili Hong, Xiaosi Lin, Diaozhu Liu, Yujia Huang, Chulin Wang, Gang Li, Feng Sun, Chenglin Chen, Chaogang Lu, Jiahui Qi, Yiqin Wang, Chuan Li, Yan Xu, Mingtong Ren, Meng Yang, Chuan Wang, Guixia Yan, Li |
author_facet | Sun, Kan Xiao, Xianchao You, Lili Hong, Xiaosi Lin, Diaozhu Liu, Yujia Huang, Chulin Wang, Gang Li, Feng Sun, Chenglin Chen, Chaogang Lu, Jiahui Qi, Yiqin Wang, Chuan Li, Yan Xu, Mingtong Ren, Meng Yang, Chuan Wang, Guixia Yan, Li |
author_sort | Sun, Kan |
collection | PubMed |
description | A tool was constructed to assess need of an oral glucose tolerance test (OGTT) in patients whose fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are normal. Data was collected from the longitudinal REACTION study conducted from June to November 2011 (14,686 subjects, aged ≥ 40 y). In people without a prior history of diabetes, isolated high 2-hour plasma glucose was defined as 2-hour plasma glucose ≥ 11.1 mmol/L, FPG < 7.0 mmol/L, and HbA1c < 6.5%. A predictive nomogram for high 2-hour plasma glucose was developed via stepwise logistic regression. Discrimination and calibration of the nomogram were evaluated by the area under the receiver operating characteristic curve (AUC) and Hosmer-Lemeshow test; performance was externally validated in Northeast China. Parameters in the model included gender, age, drinking status, marriage status, history of hypertension and hyperlipidemia, waist-to-hip ratio, FPG, and HbA1c. All variables were noninvasive, except FPG and HbA1c. The AUC of the nomogram for isolated high 2-hour plasma glucose was 0.759 (0.727-0.791) in the development dataset. The AUCs of the internal and externally validation datasets were 0.781 (0.712-0.833) and 0.803 (0.778-0.829), respectively. Application of the nomogram during the validation study showed good calibration, and the decision curve analysis indicated that the nomogram was clinically useful. This practical nomogram model may be a reliable screening tool to detect isolated high 2-hour plasma glucose for individualized assessment in patients with normal FPG and HbA1c. It should simplify clinical practice, and help clinicians in decision-making. |
format | Online Article Text |
id | pubmed-9492843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94928432022-09-23 Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose Sun, Kan Xiao, Xianchao You, Lili Hong, Xiaosi Lin, Diaozhu Liu, Yujia Huang, Chulin Wang, Gang Li, Feng Sun, Chenglin Chen, Chaogang Lu, Jiahui Qi, Yiqin Wang, Chuan Li, Yan Xu, Mingtong Ren, Meng Yang, Chuan Wang, Guixia Yan, Li Front Endocrinol (Lausanne) Endocrinology A tool was constructed to assess need of an oral glucose tolerance test (OGTT) in patients whose fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are normal. Data was collected from the longitudinal REACTION study conducted from June to November 2011 (14,686 subjects, aged ≥ 40 y). In people without a prior history of diabetes, isolated high 2-hour plasma glucose was defined as 2-hour plasma glucose ≥ 11.1 mmol/L, FPG < 7.0 mmol/L, and HbA1c < 6.5%. A predictive nomogram for high 2-hour plasma glucose was developed via stepwise logistic regression. Discrimination and calibration of the nomogram were evaluated by the area under the receiver operating characteristic curve (AUC) and Hosmer-Lemeshow test; performance was externally validated in Northeast China. Parameters in the model included gender, age, drinking status, marriage status, history of hypertension and hyperlipidemia, waist-to-hip ratio, FPG, and HbA1c. All variables were noninvasive, except FPG and HbA1c. The AUC of the nomogram for isolated high 2-hour plasma glucose was 0.759 (0.727-0.791) in the development dataset. The AUCs of the internal and externally validation datasets were 0.781 (0.712-0.833) and 0.803 (0.778-0.829), respectively. Application of the nomogram during the validation study showed good calibration, and the decision curve analysis indicated that the nomogram was clinically useful. This practical nomogram model may be a reliable screening tool to detect isolated high 2-hour plasma glucose for individualized assessment in patients with normal FPG and HbA1c. It should simplify clinical practice, and help clinicians in decision-making. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9492843/ /pubmed/36157464 http://dx.doi.org/10.3389/fendo.2022.943750 Text en Copyright © 2022 Sun, Xiao, You, Hong, Lin, Liu, Huang, Wang, Li, Sun, Chen, Lu, Qi, Wang, Li, Xu, Ren, Yang, Wang and Yan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Sun, Kan Xiao, Xianchao You, Lili Hong, Xiaosi Lin, Diaozhu Liu, Yujia Huang, Chulin Wang, Gang Li, Feng Sun, Chenglin Chen, Chaogang Lu, Jiahui Qi, Yiqin Wang, Chuan Li, Yan Xu, Mingtong Ren, Meng Yang, Chuan Wang, Guixia Yan, Li Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title | Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title_full | Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title_fullStr | Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title_full_unstemmed | Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title_short | Development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
title_sort | development and validation of a nomogram for assessing risk of isolated high 2-hour plasma glucose |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492843/ https://www.ncbi.nlm.nih.gov/pubmed/36157464 http://dx.doi.org/10.3389/fendo.2022.943750 |
work_keys_str_mv | AT sunkan developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT xiaoxianchao developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT youlili developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT hongxiaosi developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT lindiaozhu developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT liuyujia developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT huangchulin developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT wanggang developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT lifeng developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT sunchenglin developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT chenchaogang developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT lujiahui developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT qiyiqin developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT wangchuan developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT liyan developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT xumingtong developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT renmeng developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT yangchuan developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT wangguixia developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose AT yanli developmentandvalidationofanomogramforassessingriskofisolatedhigh2hourplasmaglucose |