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Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gra...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492851/ https://www.ncbi.nlm.nih.gov/pubmed/36160844 http://dx.doi.org/10.3389/fphys.2022.976926 |
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author | Clément, Gilles Rittweger, Jörn Nitsche, Andrea Doering, Wolfgang Frings-Meuthen, Petra Hand, Olga Frett, Timo Noppe, Alexandra Paulke, Freia Lecheler, Leopold Jordan, Jens Stern, Claudia Mulder, Edwin |
author_facet | Clément, Gilles Rittweger, Jörn Nitsche, Andrea Doering, Wolfgang Frings-Meuthen, Petra Hand, Olga Frett, Timo Noppe, Alexandra Paulke, Freia Lecheler, Leopold Jordan, Jens Stern, Claudia Mulder, Edwin |
author_sort | Clément, Gilles |
collection | PubMed |
description | A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA. |
format | Online Article Text |
id | pubmed-9492851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94928512022-09-23 Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study Clément, Gilles Rittweger, Jörn Nitsche, Andrea Doering, Wolfgang Frings-Meuthen, Petra Hand, Olga Frett, Timo Noppe, Alexandra Paulke, Freia Lecheler, Leopold Jordan, Jens Stern, Claudia Mulder, Edwin Front Physiol Physiology A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9492851/ /pubmed/36160844 http://dx.doi.org/10.3389/fphys.2022.976926 Text en Copyright © 2022 Clément, Rittweger, Nitsche, Doering, Frings-Meuthen, Hand, Frett, Noppe, Paulke, Lecheler, Jordan, Stern and Mulder. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Clément, Gilles Rittweger, Jörn Nitsche, Andrea Doering, Wolfgang Frings-Meuthen, Petra Hand, Olga Frett, Timo Noppe, Alexandra Paulke, Freia Lecheler, Leopold Jordan, Jens Stern, Claudia Mulder, Edwin Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title | Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title_full | Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title_fullStr | Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title_full_unstemmed | Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title_short | Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study |
title_sort | assessing the effects of artificial gravity in an analog of long-duration spaceflight: the protocol and implementation of the agbresa bed rest study |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492851/ https://www.ncbi.nlm.nih.gov/pubmed/36160844 http://dx.doi.org/10.3389/fphys.2022.976926 |
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