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Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study

A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gra...

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Autores principales: Clément, Gilles, Rittweger, Jörn, Nitsche, Andrea, Doering, Wolfgang, Frings-Meuthen, Petra, Hand, Olga, Frett, Timo, Noppe, Alexandra, Paulke, Freia, Lecheler, Leopold, Jordan, Jens, Stern, Claudia, Mulder, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492851/
https://www.ncbi.nlm.nih.gov/pubmed/36160844
http://dx.doi.org/10.3389/fphys.2022.976926
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author Clément, Gilles
Rittweger, Jörn
Nitsche, Andrea
Doering, Wolfgang
Frings-Meuthen, Petra
Hand, Olga
Frett, Timo
Noppe, Alexandra
Paulke, Freia
Lecheler, Leopold
Jordan, Jens
Stern, Claudia
Mulder, Edwin
author_facet Clément, Gilles
Rittweger, Jörn
Nitsche, Andrea
Doering, Wolfgang
Frings-Meuthen, Petra
Hand, Olga
Frett, Timo
Noppe, Alexandra
Paulke, Freia
Lecheler, Leopold
Jordan, Jens
Stern, Claudia
Mulder, Edwin
author_sort Clément, Gilles
collection PubMed
description A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA.
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spelling pubmed-94928512022-09-23 Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study Clément, Gilles Rittweger, Jörn Nitsche, Andrea Doering, Wolfgang Frings-Meuthen, Petra Hand, Olga Frett, Timo Noppe, Alexandra Paulke, Freia Lecheler, Leopold Jordan, Jens Stern, Claudia Mulder, Edwin Front Physiol Physiology A comprehensive strategy is required to mitigate risks to astronauts’ health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9492851/ /pubmed/36160844 http://dx.doi.org/10.3389/fphys.2022.976926 Text en Copyright © 2022 Clément, Rittweger, Nitsche, Doering, Frings-Meuthen, Hand, Frett, Noppe, Paulke, Lecheler, Jordan, Stern and Mulder. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Clément, Gilles
Rittweger, Jörn
Nitsche, Andrea
Doering, Wolfgang
Frings-Meuthen, Petra
Hand, Olga
Frett, Timo
Noppe, Alexandra
Paulke, Freia
Lecheler, Leopold
Jordan, Jens
Stern, Claudia
Mulder, Edwin
Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title_full Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title_fullStr Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title_full_unstemmed Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title_short Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study
title_sort assessing the effects of artificial gravity in an analog of long-duration spaceflight: the protocol and implementation of the agbresa bed rest study
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492851/
https://www.ncbi.nlm.nih.gov/pubmed/36160844
http://dx.doi.org/10.3389/fphys.2022.976926
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